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Linaclotide as a Single Agent Bowel Preparation Regimen Before Colonoscopy.
Am Surg
November 2024
Department of Surgery, University of Florida, Gainesville, FL, USA.
Efficacy and safety of linaclotide in treatment-resistant chronic constipation: A multicenter, open-label study.
Neurogastroenterol Motil
December 2024
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Article Synopsis
- - This study assessed how effective and safe linaclotide is for treating chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) in patients who didn't respond to magnesium oxide.
- - Conducted over 12 weeks, 61 participants showed significant improvements in quality of life and bowel movement frequency, with noticeable changes in various symptoms measured on standard scales.
- - The findings suggest that linaclotide could be a viable treatment for elderly patients with CC who haven't had success with traditional treatments, although some experienced diarrhea which was manageable.
Application of linaclotide in bowel preparation for colonoscopy in patients with constipation: A prospective randomized controlled study.
J Gastroenterol Hepatol
December 2024
The First Hospital of Longyan Affiliated to Fujian Medical University, Longyan, Fujian, China.
Background And Aim: Colonoscopy plays a crucial role in the early diagnosis and treatment of colorectal cancer. Adequate bowel preparation is essential for clear visualization of the colonic mucosa and lesion detection. However, inadequate bowel preparation is common in patients with constipation, and there is no standardized preparation protocol for these patients.
View Article and Find Full Text PDFBowel preparation with linaclotide and 1 L polyethylene glycol plus ascorbic acid prior to colonoscopy in chronic constipated patients.
Scand J Gastroenterol
October 2024
Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- A study was conducted to evaluate better bowel preparation methods for patients with constipation, focusing on the effectiveness of 1 L polyethylene glycol plus ascorbic acid combined with either senna or linaclotide before colonoscopy.
- The findings showed that patients who received linaclotide had a significantly lower rate of inadequate bowel preparation (11% vs 20%) and a higher adenoma detection rate (54% vs 45%) compared to those who received senna.
- The results suggest that linaclotide enhances bowel preparation effectiveness without compromising tolerability, making it a promising alternative for constipation patients.
Efficacy of linaclotide in combination with polyethylene glycol for bowel preparation in Chinese patients undergoing colonoscopy polypectomy: protocol for a randomised controlled trial.
BMJ Open
July 2024
Department of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Background: Adequate bowel preparation is essential for successful colonoscopy and polypectomy procedures. However, a significant proportion of patients still exhibit suboptimal bowel preparation, ranging from 18% to 35%. The effectiveness of bowel preparation agents can be hampered by volume and taste, adversely affecting patient compliance and tolerance.
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