AI Article Synopsis

  • The study investigates how sleep affects the consolidation of sequence-specific learning in the primary visual cortex of mice.
  • Researchers conducted experiments by recording visual responses in mice that were exposed to repeated visual sequences to assess the impact of sleep and sleep deprivation.
  • Results showed that even brief sleep promotes learning in the visual cortex, and lack of sleep inhibits this process, which can be reversed after subsequent sleep.

Article Abstract

Study Objectives: Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.

Methods: Visually evoked potentials (VEPs) were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.

Results: Sequence plasticity occurred in V1 following as little as one hour of ad libitum sleep and increased with longer periods of sleep. Sleep deprivation blocked sequence plasticity consolidation, which recovered following subsequent sleep.

Conclusions: Sleep is required for the consolidation of sequence plasticity in mouse V1.

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Source
http://dx.doi.org/10.1093/sleep/zsae262DOI Listing

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