Study Objectives: Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.
Methods: Visually evoked potentials (VEPs) were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.
Results: Sequence plasticity occurred in V1 following as little as one hour of ad libitum sleep and increased with longer periods of sleep. Sleep deprivation blocked sequence plasticity consolidation, which recovered following subsequent sleep.
Conclusions: Sleep is required for the consolidation of sequence plasticity in mouse V1.
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http://dx.doi.org/10.1093/sleep/zsae262 | DOI Listing |
Proteins
January 2025
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, India.
The structural plasticity of proteins at the molecular level is largely dictated by backbone torsion angles, which play a critical role in ligand recognition and binding. To establish the anion-induced cooperative arrangement of the main-chain (mc) torsion, herein, we analyzed a set of naturally occurring CαNN motifs as "static models" for their anion-binding competence through docking and molecular dynamics simulations and decoded its torsion angle influenced mc-driven anion recognition potential. By comparing a pool of 20 distinct sets of CαNN motif with identical sequences in their "anion bound/present, aP" and "anion free/absent, aA" versions, we could discern that there exists a positive correlation between the "difference of anion residence time (ΔR)" and "difference among the main-chain torsion angle" of the aP and aA population.
View Article and Find Full Text PDFLab Chip
January 2025
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Nucleic acid testing (NAT) is widely considered the gold standard in analytical fields, with applications spanning environmental monitoring, forensic science and clinical diagnostics, among others. However, its widespread use is often constrained by complicated assay procedures, the need for specialized equipment, and the complexity of reagent handling. In this study, we demonstrate a fully integrated 3D-printed biosensensing device employing a CRISPR/Cas12a-based dual-enzymatic mechanism for highly sensitive and user-friendly nucleic acid detection.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Life Sciences, University of Siena, 53100, Siena, Italy.
Plastic pollution is a significant environmental challenge of contemporary age. Polystyrene (PS), among the most commonly used plastic polymers worldwide, is highly durable and difficult to degrade. Despite various disposal strategies, PS continues to impact biodiversity, human health, and ecosystems.
View Article and Find Full Text PDFBMC Biol
January 2025
Department of Evolution and Ecology, University of California Davis, Davis, CA, 95616, USA.
Background: Rapid morphological change is emerging as a consequence of climate change in many systems. It is intuitive to hypothesize that temporal morphological trends are driven by the same selective pressures that have established well-known ecogeographic patterns over spatial environmental gradients (e.g.
View Article and Find Full Text PDFStroke
January 2025
New Drug Screening Center, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (H.S., H.W., C.W., G.L., M.H., H.Z., F.H., H.L.).
Background: Activating glutamatergic neurons in the ipsilesional motor cortex can promote functional recovery after stroke. However, the underlying molecular mechanisms remain unclear. Clarifying key molecular mechanisms involved in recovery could help understand the development of neuromodulation strategies after stroke.
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