High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638908 | PMC |
| http://dx.doi.org/10.1158/2767-9764.CRC-24-0164 | DOI Listing |
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