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Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter.
Front Pharmacol
January 2025
Center for Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Background: In China, 80% of Hepatocellular Carcinoma (HCC) is associated with cirrhosis. Portal hypertension, the most common outcome of cirrhosis progression, has a high incidence. Platelet count/spleen diameter ratio (PSL) with a cut-off value of 909 can predict the presence of esophagogastric varices and thus portal hypertension, which is also an independent risk factor for early recurrence and late recurrence of hepatocellular carcinoma after resection.
View Article and Find Full Text PDFDiscovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC-MS/MS peptidome analysis.
Sci Rep
January 2025
Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Cholangiocarcinoma (CCA) is an aggressive cancer originating from bile duct epithelial cells, with a high rate of recurrence following surgical resection. Recurrence is categorized as early linked to aggressive tumor biology than late recurrence. This study aimed to identify novel peptide mass fingerprints (PMFs) and potential biomarker panels in the serum of CCA patients with early and late recurrence using mass spectrometry.
View Article and Find Full Text PDFBlue light cystoscopy- as an improvised diagnostic modality for bladder tumours.
J Pak Med Assoc
January 2025
Department of Physiology, Karachi University, Karachi, Pakistan.
Bladder cancer remains a significant global health concern, being the 10th most common malignancy worldwide and the 6th most common neoplasia in males, with alarming annual incidence and mortality rates. The current narrative review was planned to delve into the multifaceted landscape of bladder cancer, exploring its epidemiology, risk factors and diagnostic modalities. While white light cystoscopy has long been considered the gold standard for bladder cancer diagnosis and surveillance, the emergence of blue light cystoscopy has ushered in a new era of early detection.
View Article and Find Full Text PDFLong-term outcome after a limb salvage procedure using a femoral head allograft following the resection of a synovial sarcoma affecting the hindfoot.
BMJ Case Rep
January 2025
Department of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile, Santiago, RM, Chile
The hindfoot is an uncommon site for malignant tumours. While limb salvage procedures are now more common for treating bone sarcoma, there is limited information available on hindfoot reconstruction alternatives because of its low incidence and its challenging outcomes. We present a case report of a man in his late 60s with synovial sarcoma affecting the right heel (calcaneus and soft tissue).
View Article and Find Full Text PDFPandemic driven preoperative moderate hypofractionated radiotherapy for soft tissue sarcomas.
Eur J Cancer
January 2025
Department of Radiotherapy, Leiden University Medical Centre, the Netherlands. Electronic address:
Purpose: Moderate hypofractionation was adopted to reduce hospital visits during the COVID-19 pandemic aiming to maintain treatment efficacy for soft tissue sarcoma (STS) patients, shifting preoperative schedules from 25 fractions of 2 Gy to 14-15 fractions of 3 Gy. This study evaluates the clinical implications and outcomes of this schedule, focusing on wound complications, radiation toxicity, local tumour control, and distant metastases.
Patients And Methods: Data was collected from patients treated between 01 and 01-2020 and 31-12-2023.
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