Vinyl units intrinsically featuring less steric, nonpolarity, and unsaturated character, are well-known π-bridge used in the synthesis of high-performance semiconducting materials. Two-dimensional (2D) vinylene-linked covalent organic frameworks (COFs) represent a promising class of π-conjugated structures, however, the range of available monomers for the reversible formation of carbon-carbon double bonds remains limited. In this study, a new class of 2D vinylene-linked COFs were synthesized using dimethyldiketopyrrolopyrrole (DM-DPP) as the key monomer. The strong electron deficiency of diketopyrrolopyrrole (DPP) makes its methyl substituents readily activated upon the cocatalysis of L-proline and 4-dimethylaminopyridine in aqueous solution to conduct dynamic condensation with tritopic aromatic aldehydes. The resulting COFs crystallized in an eclipsed AA stacking arrangement and featured abundant, regular nanochannels. Their robust vinyl DPP-linking mode enhanced donor-π-acceptor conjugation and promoted π-stacked alignment along the vertical direction. Consequently, the synthesized COFs exhibited band gaps as narrow as 1.02 eV and demonstrated excellent light-harvesting capability across the visible to near-infrared I (NIR-I) regions. Furthermore, the COFs could be converted into free-standing thin pellets through simple pressure casting, and show excellent photothermal response and cycling stability under different light sources.
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http://dx.doi.org/10.1002/anie.202417805 | DOI Listing |
Virology
December 2024
Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY, USA.
Positive-strand (+)RNA viruses are major pathogens of humans, animals and plants. This review summarizes the complex interplay between the host autophagy pathway and Tomato bushy stunt virus (TBSV) replication. Recent discoveries with TBSV have revealed virus-driven exploitation of autophagy in multiple ways that contributes to the unique phospholipid composition of viral replication organellar (VROs) membranes.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Cellular activity is spatially organized across different organelles. While several structures are well-characterized, many organelles have unknown roles. Profiling biomolecular composition is key to understanding function but is difficult to achieve in the context of small, dynamic structures.
View Article and Find Full Text PDFTrends Plant Sci
December 2024
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543, Singapore. Electronic address:
Epitranscriptomic regulation has emerged as a crucial layer of gene control where RNA modifications, particularly N-methyladenosine (mA), introduce complexity and versatility to gene regulation. Increasing evidence suggests that epitranscriptomic regulation through phase separation plays critical roles in mediating RNA metabolism during plant development and stress responses. mA-associated biomolecular condensates formed via phase separation act as dynamic cellular hotspots where mA effectors, RNAs, and other regulatory proteins coalesce to facilitate RNA regulation.
View Article and Find Full Text PDFJ Lipid Res
December 2024
Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan. Electronic address:
Nuclear lipids play roles in regulatory processes such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis. In COS-7 cells, nuclear lipids are enriched at the perichromosomal layer and excluded from intrachromosomal regions during early mitosis, but are then detected in intrachromosomal regions during late mitosis, as revealed by TT-ExM, an improved expansion microscopy technique that enables high-sensitivity, super-resolution imaging of proteins, lipids, and nuclear DNA.
View Article and Find Full Text PDFMol Cell
December 2024
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:
In this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.
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