Objectives: Cervical cancer, a leading cause of cancer-related deaths among women globally, has a significantly higher survival rate when diagnosed early. Traditional diagnostic methods like Pap smears and cervical biopsies rely heavily on the skills of cytologists, making the process prone to errors. This study aims to develop CerviXpert, a multi-structural convolutional neural network designed to classify cervix types and detect cervical cell abnormalities efficiently.
Methods: We introduced CerviXpert, a computationally efficient convolutional neural network model that classifies cervical cancer using images from the publicly available SiPaKMeD dataset. Our approach emphasizes simplicity, using a limited number of convolutional layers followed by max-pooling and dense layers, trained from scratch. We compared CerviXpert's performance against other state-of-the-art convolutional neural network models, including ResNet50, VGG16, MobileNetV2, and InceptionV3, evaluating them on accuracy, computational efficiency, and robustness using five-fold cross-validation.
Results: CerviXpert achieved an accuracy of 98.04% in classifying cervical cell abnormalities into three classes (normal, abnormal, and benign) and 98.60% for five-class cervix type classification, outperforming MobileNetV2 and InceptionV3 in both accuracy and computational demands. It demonstrated comparable results to ResNet50 and VGG16, with significantly reduced computational complexity and resource usage.
Conclusion: CerviXpert offers a promising solution for efficient cervical cancer screening and diagnosis, striking a balance between accuracy and computational feasibility. Its streamlined architecture makes it suitable for deployment in resource-constrained environments, potentially improving early detection and management of cervical cancer.
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http://dx.doi.org/10.1177/20552076241295440 | DOI Listing |
BMC Bioinformatics
January 2025
Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100190, China.
In recent years, combined drug screening has played a very important role in modern drug discovery. Generally, synergistic drug combinations are crucial in treatment for many diseases. However, the toxic side effects of drug combinations are probably increased with the increase of drugs numbers, so the accurate prediction of toxic side effects of drug combinations is equally important.
View Article and Find Full Text PDFCommun Biol
January 2025
University of Twente, Enschede, The Netherlands.
Deep learning classification models based on Convolutional Neural Networks (CNNs) are increasingly used in population genetic inference for detecting signatures of natural selection. Prevailing detection methods treat the design of the classifier as a discrete phase, assuming that high classification accuracy is the sole prerequisite for precise detection. This frequently steers method development toward classification-driven optimizations that can inadvertently impede detection.
View Article and Find Full Text PDFSci Rep
January 2025
Zhongyu (Fujian) Digital Technology Co., Ltd, Fuzhou, 350108, China.
Attention mechanisms have been introduced to exploit deep-level information for image restoration by capturing feature dependencies. However, existing attention mechanisms often have limited perceptual capabilities and are incompatible with low-power devices due to computational resource constraints. Therefore, we propose a feature enhanced cascading attention network (FECAN) that introduces a novel feature enhanced cascading attention (FECA) mechanism, consisting of enhanced shuffle attention (ESA) and multi-scale large separable kernel attention (MLSKA).
View Article and Find Full Text PDFSci Rep
January 2025
Hive AI Innovation Studio, Department of Computer Science and Engineering, University of Louisville, Louisville, KY, 40292, USA.
Nailfold Capillaroscopy (NFC) is a simple, non-invasive diagnostic tool used to detect microvascular changes in nailfold. Chronic pathological changes associated with a wide range of systemic diseases, such as diabetes, cardiovascular disorders, and rheumatological conditions like systemic sclerosis, can manifest as observable microvascular changes in the terminal capillaries of nailfolds. The current gold standard relies on experts performing manual evaluations, which is an exhaustive time-intensive, and subjective process.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Rehabilitation Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Accurately extracting organs from medical images provides radiologist with more comprehensive evidences to clinical diagnose, which offers up a higher accuracy and efficiency. However, the key to achieving accurate segmentation lies in abundant clues for contour distinction, which has a high demand for the network architecture design and its practical training status. To this end, we design auxiliary and refined constraints to optimize the energy function by supplying additional guidance in training procedure, thus promoting model's ability to capture information.
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