AI Article Synopsis

  • The study evaluates the practicality of using Raman spectroscopy for identifying parathyroid glands during thyroid surgery.
  • Researchers collected 324 Raman spectra from various tissues in 10 Wistar rats, focusing on thyroid, lymph node, parathyroid gland, and lipid.
  • The analysis showed highly accurate detection rates (98.4% for parathyroid, 93.9% for lymph node, 95.4% for thyroid), indicating that Raman spectroscopy could effectively aid in protecting the parathyroid glands during surgery.

Article Abstract

We aim to evaluate the feasibility of Raman spectroscopy for parathyroid gland (PG) identification during thyroidectomy. Using a novel side-viewing handheld Raman probe, a total of 324 Raman spectra of four tissue types (i.e., thyroid, lymph node, PG, and lipid) commonly encountered during thyroidectomy were rapidly (< 3 s) acquired from 80 tissue sites (thyroid [n = 10], lymph node [n = 10], PG [n = 40], lipid [n = 20]) of 10 euthanized Wistar rats. Two partial least-squares (PLS)-discriminant analysis (DA) detection models were developed, differentiating the lipid and nonlipid (i.e., thyroid, lymph node, and PG) tissues with an accuracy of 100%, and PG, lymph node, and thyroid could be detected with an accuracy of 98.4%, 93.9%, and 95.4% respectively. This work demonstrates the feasibility of Raman spectroscopy technique for PG identification and protection during thyroidectomy at the molecular level.

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Source
http://dx.doi.org/10.1002/jbio.202400220DOI Listing

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