AI Article Synopsis
- Ovarian cancer often leads to muscle loss, malnutrition, and fatigue, adversely affecting patients' quality of life, especially during first-line chemotherapy.
- A new study aims to assess an app-based exercise and nutrition program's effectiveness over six months compared to standard care, with physical performance measured by the 6-Minute Walk Test as the main focus.
- The study will involve a multicenter trial with a minimum of 182 participants, all diagnosed with advanced ovarian cancer, and assess various health and nutrition indicators alongside physical performance improvements.
Article Abstract
Background: In ovarian cancer frequently reported side effects are muscle wasting and malnutrition, leading to frailty, decreased health-related quality of life (HRQoL), and cancer-related fatigue (CRF). Both often begin during first-line chemotherapy and develop progressively into a refractory state, if left untreated.
Method: Primary objective is to evaluate effectiveness of a newly developed app-based exercise and nutrition program under non-standardized conditions of clinical routine. We hypothize that patients who receive an individually tailored exercise and nutrition program for six months will have improved physical performance compared to patients who receive usual care. This is a multicenter randomized controlled open-label trial comparing an intervention group receiving a six-month exercise and nutrition intervention and a control group receiving usual care. Primary endpoint is the change in 6-Minute Walk Test (6MWT) from baseline to T2 (26 weeks after baseline) as a measure of physical functioning. Secondary endpoints include patients' utilization and adherence to the nutrition program (MEDAS), their malnutrition risk (NRS2002), as well as patients' HRQoL (see Table 1). Using the two-sample t-test with a two-sided type I error of 5% and 80% power, a medium effect size of Cohen's d = 0.50 can be demonstrated with a minimum of 128 participants (64 per group). With a conservatively estimated dropout rate of 30%, 182 patients will be recruited. Patients who are included must be over 18 years of age, be diagnosed with ovarian cancer, cancer of fallopian tubes, or peritoneal cancer, FIGO stages II-IV, receive surgery and chemotherapy (adjuvant or neoadjuvant). Exclusion criteria are an ECOG status greater than 2, inadequate proficiency in German, or physical or mental impairments hindering the implementation of the program or execution of study procedures.
Discussion: In case of success, the project contributes in the long term to (i) improving medical care (diagnosis, psychoeducation, patient orientation, and empowerment), (ii) reducing the burden of disease and promoting physical autonomy for patients, and (iii) being incorporated into relevant guidelines.
Trial Registration: The study was registered at ClinicalTrials.gov (NCT06250686).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552146 | PMC |
| http://dx.doi.org/10.1186/s12885-024-13102-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations between parent and adolescent weight outcomes within two parent approaches to family-based adolescent obesity treatment: Secondary analyses from the TEENS+ pilot trial.
Pediatr Obes
January 2025
Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia, USA.
Objective: To examine associations between parent and adolescent weight change within two parent approaches to adolescent obesity treatment.
Methods: Adolescent (M = 13.7 ± 1.
Mechanisms and pharmacotherapy of cancer cachexia-associated anorexia.
Pharmacol Res Perspect
February 2025
Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
Cachexia is a multifactorial metabolic syndrome characterized by weight and skeletal muscle loss caused by underlying illnesses such as cancer, heart failure, and renal failure. Inflammation, insulin resistance, increased muscle protein degradation, decreased food intake, and anorexia are the primary pathophysiological drivers of cachexia. Cachexia causes physical deterioration and functional impairment, loss of quality of life, lower response to active treatment, and ultimately morbidity and mortality, while the difficulties in tackling cachexia in its advanced phases and the heterogeneity of the syndrome among patients require an individualized and multidisciplinary approach from an early stage.
View Article and Find Full Text PDFCoffee drinking timing and mortality in US adults.
Eur Heart J
January 2025
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA.
Background And Aims: To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.
Methods: This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999-2018 who had complete information on dietary data and 1463 adults from the Women's and Men's Lifestyle Validation Study who had complete data on 7-day dietary record. Clustering analysis was used to identify patterns of coffee drinking timing.
Optimisation of the patient having oncological surgical through prehabilitation: a narrative review.
Anaesthesia
January 2025
Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Introduction: Prehabilitation aims to improve physiological reserve and psychological resilience, enabling patients to better tolerate the physiological stress of major surgery, thereby reducing the risk of complications and improving surgical outcomes. In this review, we provide an update of the development of prehabilitation in patients having cancer surgery.
Methods: We searched databases of peer-reviewed research to identify appropriate papers.
Next-generation diabetes diagnosis and personalized diet-activity management: A hybrid ensemble paradigm.
PLoS One
January 2025
Department of Information Systems, College of Computer Sciences and Information Technology (CCSIT), King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
Diabetes, a chronic metabolic condition characterised by persistently high blood sugar levels, necessitates early detection to mitigate its risks. Inadequate dietary choices can contribute to various health complications, emphasising the importance of personalised nutrition interventions. However, real-time selection of diets tailored to individual nutritional needs is challenging because of the intricate nature of foods and the abundance of dietary sources.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!