AI Article Synopsis
- Neurodegenerative diseases, like Parkinson's and Alzheimer's, are becoming more common in younger individuals due to lifestyle and environmental changes.
- These diseases are characterized by the progressive loss of neurons in the nervous system.
- Mitochondrial dysfunction, which affects ATP production in the brain, is increasingly recognized as a key factor in these diseases and may lead to new treatment approaches.
Article Abstract
Neurodegenerative diseases, as common diseases in the elderly, tend to become younger due to environmental changes, social development and other factors. They are mainly characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system, and common diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease and so on. Mitochondria are important organelles for adenosine triphosphate (ATP) production in the brain. In recent years, a large amount of evidence has shown that mitochondrial dysfunction plays a direct role in neurodegenerative diseases, which is expected to provide new ideas for the treatment of related diseases. This review will summarize the main mechanisms of mitochondrial dysfunction in neurodegenerative diseases, as well as collating recent advances in the study of mitochondrial disorders and new therapies.
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| http://dx.doi.org/10.1016/j.arr.2024.102577 | DOI Listing |
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