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[Immune thrombocytopenia: current diagnostics and therapy : The new 2023 expert report in brief].
Inn Med (Heidelb)
December 2024
Medizinische Klinik, Innere Medizin II, Hämatologie, Onkologie, klinische Immunologie und Rheumatologie, Universitätsklinikum Tübingen, Universität Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland.
Immune thrombocytopenia (ITP) is an acquired thrombocytopenia caused by an autoimmune reaction against platelets in the blood and against megakaryocytes in the bone marrow. The indication for treatment is based on the bleeding symptoms and patient-specific factors. This article presents the current 2023 expert report that also forms the basis for the updated version of the Onkopedia guideline, which is expected in the course of 2024.
View Article and Find Full Text PDFONKOPEDIA Guideline Updates "in a Nutshell" for the Readers of Oncology Research and Treatment.
Oncol Res Treat
November 2024
Klinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Radiological Assessment of Different Retroperitoneal Lymph Node Measurements in Stage 1 Testicular Cancer Patients: Impact on Clinical Stage and Treatment.
J Clin Med
September 2024
Department of Urology, Federal Armed Forces Hospital Koblenz, 56072 Koblenz, Germany.
In staging for testicular germ cell tumor (GCT), current guidelines lack consensus regarding the measurement of retroperitoneal lymph node metastasis, concerning the recommended plane and dimension. This exploratory study aimed to assess its impact on clinical stage (cS) and therapy. We retrospectively examined 154 cSI (retroperitoneal lymph nodes < 10 mm in axial short-axis diameter (SAD)) GCT patients, without adjuvant therapy and a follow-up ≥ 24 months.
View Article and Find Full Text PDFGuidelines of Onkopedia: What Is New? Locally Advanced Rectal Cancer.
Oncol Res Treat
December 2024
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO) Berlin, Berlin, Germany.
This article briefly summarizes clinically relevant new aspects of the recently published German, Austrian, and Swiss Onkopedia guideline for the treatment of locally advanced rectal cancer. Main aspects comprise (i) the use of total neoadjuvant therapy for rectal cancers with high-risk features, (ii) treatment with neoadjuvant chemotherapy for patients with a low risk for local recurrence, (iii) immunotherapy using dostarlimab in patients with MSI high/dMMR rectal cancer, as well as (iv) the implementation of organ sparing treatment concepts. The availability of several evidence-based treatment options requires intensive discussion within the multidisciplinary team as well as dedicated information for patients about treatment goals, options, and risks of individual treatment approaches.
View Article and Find Full Text PDFBackground: While the "7+3" regimen of cytarabine + anthracycline has been the backbone of acute myeloid leukemia (AML) treatment for four decades, several novel drugs have been approved in the past five years. Despite these promising novel therapeutic options, treatment of AML remains challenging, given the biologically heterogenous character of the disease.
Aim: This review provides an update on novel treatment strategies for AML.
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