AI Article Synopsis
- Durvalumab plus tremelimumab (STRIDE) is a new treatment for unresectable hepatocellular carcinoma (uHCC), but real-world data on its effectiveness is limited.
- A study assessed 21 patients treated with STRIDE, finding an objective response rate of 52.4% and a median progression-free survival of 6.8 months.
- A high tumor-to-liver ratio on FDG-PET scans was linked to a better response, suggesting it could serve as a useful biomarker for patient outcomes.
Article Abstract
Introduction: Durvalumab plus tremelimumab combination therapy (STRIDE regimen) is a new first-line option for unresectable hepatocellular carcinoma (uHCC), but little real-world data are available to determine which patients are most likely to respond.
Methods: This study retrospectively evaluated patients with uHCC who were treated with the STRIDE regimen as the 1st line at our hospital. The primary endpoint of the study was the objective response rate (ORR). We focused on identifying factors associated with cases that had a favorable response.
Results: Twenty-one patients were included. In best response, there were 11 partial response cases, with an ORR of 52.4%. Median progression-free survival was 6.8 months, and overall survival did not reach the median time. A high tumor-to-liver ratio of the maximum value of the standardized uptake value (TLR) on baseline fluorodeoxyglucose positron emission tomography (FDG-PET) was associated with response, while TLRs were significantly higher in poorly differentiated uHCC.
Conclusion: The STRIDE regimen may be beneficial for systemic therapy-naive uHCC patients. High TLR on baseline FDG-PET could be a potentially useful biomarker for response.
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| http://dx.doi.org/10.1159/000542517 | DOI Listing |
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