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Association of Sleep Spindle Rate With Memory Consolidation in Children With Rolandic Epilepsy.
Neurology
January 2025
Department of Neurology, Massachusetts General Hospital, Boston.
Background And Objectives: Rolandic epilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models and healthy controls. Sleep spindles are decreased in RE and related sleep-activated epileptic encephalopathies.
View Article and Find Full Text PDFA novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes.
MethodsX
June 2025
Medical College of Wisconsin, Department of Neurosurgery, 8701 Watertown Plank Road, Milwaukee, WI, 53226.
Electrographic recording of brain activity through either surface electrodes (electroencephalography, EEG) or implanted electrodes (electrocorticography, ECOG) are valuable research tools in neuroscience across many disciplines, including epilepsy, sleep science and more. Research techniques to perform recordings in rodents are wide-ranging and often require custom parts that may not be readily available. Moreover, the information required to connect individual components is often limited and can therefore be challenging to implement.
View Article and Find Full Text PDFPotential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report.
JA Clin Rep
December 2024
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background: Local anesthetic systemic toxicity (LAST) is a rare but potentially life-threatening complication. Under general anesthesia, neurological signs are often masked, delaying diagnosis and increasing the risk of sudden cardiovascular collapse. Therefore, early detection methods are critically needed.
View Article and Find Full Text PDFElectroencephalographic (EEG) Stages in Patients With Cerebral Edema Following Cardiac Arrest.
J Child Neurol
November 2024
Division of Epilepsy and Neurophysiology, Children's National Hospital, Washington DC, USA.
Objective: To describe electroencephalographic (EEG) changes in pediatric patients with cerebral edema after cardiac arrest.
Methods: A retrospective study of patients admitted to the pediatric intensive care unit from July 2021 to January 2023. We included patients with cardiac arrest and changes in EEG background with clinical changes and/or neuroimaging consistent with cerebral edema.
PTEN deletion in the adult dentate gyrus induces epilepsy.
Neurobiol Dis
December 2024
Reeve-Irvine Research Center, Gillespie Neuroscience Research Facility, 837 Health Sciences Road, University of California at Irvine, Irvine, CA 92697, USA; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA 92697, USA; Department of Neurobiology & Behavior, University of California at Irvine, Irvine, CA 92697, USA; Department of Neurosurgery, University of California at Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA 92697, USA; University of California at Irvine School of Medicine, Irvine, CA, 92697, USA. Electronic address:
Embryonic and early postnatal promotor-driven deletion of the phosphatase and tensin homolog (PTEN) gene results in neuronal hypertrophy, hyperexcitable circuitry and development of spontaneous seizures in adulthood. We previously documented that focal, vector-mediated PTEN deletion in mature granule cells of the adult dentate gyrus triggers dramatic growth of cell bodies, dendrites, and axons, similar to that seen with early postnatal PTEN deletion. Here, we assess the functional consequences of focal, adult PTEN deletion, focusing on its pro-epileptogenic potential.
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