Introduction: Endodontic retreatment procedures with calcium silicate-based sealers (CSS) have been receiving greater credibility in clinically challenging situations. The objective of this systematic review was to analyze the published studies for the retrievability of CSS in comparison to resin-based sealers evaluated using micro-computed tomography (micro-CT) in terms of the volume of the residual root canal filling materials, time taken, efficacy of the solvent, and different systems used during the retreatment procedure.
Methods: The study protocol was registered in the International Prospective Register of Systematic Reviews and conducted in adherence to PRISMA 2020 checklist. Accordingly, an electronic literature search was done to identify studies published in English language, within the time frame from January 2004 to June 2024. The search was conducted through popular databases including PubMed (Medline - National Library of Medicine), Scopus (Science Direct), EMBASE and Google Scholar following the inclusion and exclusion criteria answering the research question in focus.
Results: After thorough scrutiny, 15 studies qualified for the systematic review. Following retreatment, in all of the studies pre-treatment working length was achieved, with both the types of endodontic sealers. However, none of the micro-CT studies reported complete removal of endodontic filling material from the root canals. Irrespective of the sealer type used, within each root canal, apical third had the greatest amount of remaining filling material, followed by the middle and coronal thirds.
Conclusions: Retreatment of canals obturated with bioceramic sealers is feasible in most cases using traditional instruments and techniques. Active irrigation and supplemental mechanical removal, which employs lasers, XP-Finisher, and ultrasonics, adds advantage to maximize material removal.
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http://dx.doi.org/10.1016/j.sdentj.2024.09.011 | DOI Listing |
Cancer Treat Rev
January 2025
Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA, United States. Electronic address:
Background: Trastuzumab deruxtecan (T-DXd) has shown promising activity in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) and central nervous system (CNS) involvement. In this updated meta-analysis, we explore the effectiveness of T-DXd in a large subset of patients with HER2-positive BC and CNS disease.
Methods: A systematic search was made on September 16th, 2024, for studies investigating T-DXd in the scenario of HER2-positive BC and brain metastases (BMs) and/or leptomeningeal disease (LMD).
Clin Neuropharmacol
January 2025
Eastern Virginia Medical School, Norfolk, VA.
Objectives: This study reviews literature on the psychiatric effects of delta-8-THC, particularly psychosis and severe mental health outcomes, to highlight the need for further research and regulation.
Background: Marijuana, the most widely used illicit drug in the United States, sees increasing use due to legalization. Although moderate use is generally safe, adverse effects can occur, especially in those with preexisting conditions.
Clin Neuropharmacol
January 2025
MedStar Georgetown University Hospital, Washington, DC.
Introduction: Adjunctive therapies to treat OFF episodes resulting from long-term levodopa treatment in Parkinson disease (PD) are hampered by safety and tolerability issues. Istradefylline offers an alternative mechanism (adenosine A2A receptor antagonist) and therefore potentially improved tolerability.
Methods: A systematic review of PD adjuncts published in 2011 was updated to include randomized controlled trials published from January 1, 2010-April 15, 2019.
Ann Intern Med
January 2025
Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System; Department of Population Health Sciences, Duke University School of Medicine; and Durham Evidence Synthesis Program, Durham Veterans Affairs Health Care System, Durham, North Carolina (J.M.G.).
Background: Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear.
Purpose: To assess the effects of PDC on 30-day emergency department (ED) visits, 30-day hospital readmissions, and patient satisfaction.
Data Sources: MEDLINE, Embase, and CINAHL searched from 2012 to 25 May 2023.
J Neurosurg Case Lessons
January 2025
Division of Neurosurgery, Department of Surgery, Hospital Ignacio Pirovano, Buenos Aires, Argentina.
Background: Resection of calcified meningiomas in the ventral thoracic spinal canal remains a formidable surgical challenge despite advances in technology and refined microsurgical techniques. These tumors, which account for a small percentage of spinal meningiomas, are characterized by their hardness, complicating safe resection and often resulting in worse outcomes than their noncalcified counterparts.
Observations: The authors present the case of a 68-year-old woman with a ventrally located ossified meningioma at the T9-10 level, successfully treated via a posterolateral transpedicular approach.
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