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Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain. | LitMetric

AI Article Synopsis

  • Lipedema is a painful fat distribution disorder primarily affecting women, and its causes are thought to involve issues with fat cell development, inflammation, and changes in connective tissue.
  • A study analyzed the gene expression in subcutaneous tissue from different stages of lipedema, identifying genes linked to fat cell formation, lipid accumulation, inflammation, and pain sensitivity.
  • The research indicates that the mechanisms behind lipedema involve unique changes compared to regular fat tissue, influencing its development and resulting in the disease's symptoms.

Article Abstract

Background: Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified.

Methods: A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583).

Results: We identified several differentially expressed genes involved in mechanisms leading to the development of lipedema. Some genes, such as , , , , , and , are involved in adipogenesis, regulating the development of mature adipocytes from mesenchymal stem cells. Other genes, such as , , , , , , , , and , are predicted to be involved in lipid accumulation, hypertrophy, and the inflammation process. Further genes such as , , and are predicted to be involved in the regulation and transmission of pain.

Conclusions: In summary, the pathogenesis and development of lipedema might be caused by alterations in adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the formation of edema resulting in this painful disease. These processes differ from hypertrophied adipose tissue and may therefore play a main role in the formation of lipedema.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548906PMC
http://dx.doi.org/10.1097/GOX.0000000000006288DOI Listing

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