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http://dx.doi.org/10.1016/j.apsb.2024.05.034 | DOI Listing |
Acta Pharm Sin B
October 2024
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Sci Transl Med
April 2022
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic biomaterials are less expensive to manufacture than biologic dressings and can achieve a broader range of physiochemical properties, but opportunities remain to tailor these materials for ideal host immune and regenerative responses. Polyesters are a well-established class of synthetic biomaterials; however, acidic degradation products released by their hydrolysis can cause poorly controlled autocatalytic degradation.
View Article and Find Full Text PDFBiomaterials
December 2020
Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, PMB 351631, Nashville, TN, 37235-1631, USA. Electronic address:
Poly(ethylene glycol) (PEG) hydrogels crosslinked with enzyme-cleavable peptides are promising biodegradable vehicles for therapeutic cell delivery. However, peptide synthesis at the level required for bulk biomaterial manufacturing is costly, and fabrication of hydrogels from scalable, low-cost synthetic precursors while supporting cell-specific degradation remains a challenge. Reactive oxygen species (ROS) are cell-generated signaling molecules that can also be used as a trigger to mediate specific in vivo degradation of biomaterials.
View Article and Find Full Text PDFBiomaterials
April 2014
Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, PMB 351631, Nashville, TN 37235-1631, USA. Electronic address:
Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic breakdown products that trigger an accelerated, autocatalytic degradation mechanism that can create mismatched rates of biomaterial breakdown and tissue formation. Reactive oxygen species (ROS) are key mediators of cell function in both health and disease, especially at sites of inflammation and tissue healing, and induction of inflammation and ROS are natural components of the in vivo response to biomaterial implantation.
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