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| http://dx.doi.org/10.14797/mdcvj.1500 | DOI Listing |
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Towards personalized cardiometabolic risk prediction: A fusion of exposome and AI.
Heliyon
January 2025
Center for Applied Intelligent Systems Research, Halmstad University, Sweden.
The influence of the exposome on major health conditions like cardiovascular disease (CVD) is widely recognized. However, integrating diverse exposome factors into predictive models for personalized health assessments remains a challenge due to the complexity and variability of environmental exposures and lifestyle factors. A machine learning (ML) model designed for predicting CVD risk is introduced in this study, relying on easily accessible exposome factors.
View Article and Find Full Text PDFThe GeoTox Package: open-source software for connecting spatiotemporal exposure to individual and population-level risk.
Hum Genomics
January 2025
Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, NC, 27713, USA.
Background: Comprehensive environmental risk characterization, encompassing physical, chemical, social, ecological, and lifestyle stressors, necessitates innovative approaches to handle the escalating complexity. This is especially true when considering individual and population-level diversity, where the myriad combinations of real-world exposures magnify the combinatoric challenges. The GeoTox framework offers a tractable solution by integrating geospatial exposure data from source-to-outcome in a series of modular, interconnected steps.
View Article and Find Full Text PDFAir pollution and coronary atherosclerosis.
Future Cardiol
January 2025
Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
The recently introduced concept of 'exposome' emphasizes the impact of non-traditional threats onto cardiovascular health. Among these, air pollutants - particularly fine particulate matter < 2.5 μm (PM2.
View Article and Find Full Text PDFComprehensive analysis, comprehensive understanding: The benefit of widening the scope to uncover the complexity of human chemical exposome and tailor personalized risk assessment.
Sci Total Environ
January 2025
Human Biomonitoring Research Unit, Department of Precision Health - Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, Luxembourg. Electronic address:
While biomonitoring approaches are frequently employed for assessing chemical exposure, many of them are constrained to a limited number of target chemicals, running counter to our current understanding of interactions within chemical mixtures and the growing evidence of multiple exposures within human populations. Although authors agree on the need for more comprehensive methodologies, literature provides insufficient evidence of the multifaceted nature of exposure and of the benefit of widening the analytical scope to improve exposure assessment. Moreover, although multiple exposures are generally admitted, very few are known on the scale of the human chemical exposome.
View Article and Find Full Text PDFParental Perceptions of Early Childhood In-Home Research with Monitoring: A Qualitative Study.
J Pediatr
December 2024
Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, Chicago, IL; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:
Article Synopsis
- The study aimed to understand parents' views on using home monitoring technologies for early childhood research, focusing on their concerns and enthusiasm.
- Participants included new and expecting parents who took part in interviews about hypothetical studies involving wearable devices, audio monitoring, and environmental sampling.
- Themes from the interviews indicated that while parents were generally positive about participation, they raised concerns about safety, data privacy, and the logistical challenges of involvement, highlighting the need for trust and transparency from researchers.
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