AI Article Synopsis
- - Nephrotic syndrome (NS) is linked to a higher risk of blood clots, and although it's rare, patients can experience unexpected blood clots like deep vein thrombosis (DVT) and pulmonary embolism (PE) related to NS.
- - The case study emphasizes the difficulty in timing kidney biopsies with the need for anticoagulation treatment, especially in patients with serious or widespread blood clots.
- - The discussion includes how to choose the right anticoagulant for these patients and explores new treatment options for NS, highlighting the importance of considering individual patient risks and benefits through a team approach.
Article Abstract
Nephrotic syndrome (NS) has a well-established relationship with hypercoagulability and, while rare, is known to present with unprovoked venous thromboembolism (VTE). Here, we present a case of seemingly unprovoked deep vein thrombosis and pulmonary embolism as presenting features of NS. We explore the challenge of timing diagnostic renal biopsy with necessary therapeutic anticoagulation, particularly in patients who present with unstable or extensive VTE. We also examine relevant factors in selecting an anticoagulant and discuss emerging treatment modalities in NS. This case underscores the complexity of medical decision-making in NS presenting with VTE and highlights the importance of multi-disciplinary consideration of patient-specific risks and benefits.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549385 | PMC |
| http://dx.doi.org/10.7759/cureus.71173 | DOI Listing |
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Article Synopsis
- Nephrotic syndrome (NS) is a common kidney condition in children that can lead to severe complications like acute kidney injury (AKI), prompting the need for early identification of high-risk patients.
- A comprehensive analysis of 11 studies showed that AKI occurs in about 29% of children with NS, with several significant risk factors like age of onset, gender, serum albumin levels, steroid response, and existing conditions such as infections and hypertension.
- The study utilized traditional and network meta-analyses to evaluate these risk factors, emphasizing the importance of recognizing these associations to improve management and outcomes for children with NS.
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