Acute Focal Dystonia as a Presentation of Uncontrolled Hyperglycemia.

Cureus

Neurology, Piedmont Healthcare, Columbus, USA.

Published: October 2024

Hyperglycemia-induced involuntary movements (HIIM) include tremors, hemichorea-hemiballismus (HCHB), and more rarely, dystonia. Presentations may vary, but hyperintensity involving the basal ganglia area on the T1 sequence of MRI brain remains a commonality.  We report the occurrence of focal dystonia with uncontrolled hyperglycemia but no focal abnormalities on MRI. On admission, the patient's blood glucose was 861, and she claimed to have never missed insulin dosage. A physical exam revealed no cranial nerve abnormalities and weakness in the right upper extremity with no sensory involvement. Reflexes were 1-2+ in all extremities with down-going toes. The abnormal movements were triggered by overhead abduction of the right arm. Symptoms improved after a week with blood glucose control, as well as benzodiazepines and anticholinergics. This specific case emphasizes the occurrence of uncontrolled hyperglycemia causing movement disorders that can have normal imaging findings. Understanding the complex presentation of patients with HIIM is pivotal for effective patient diagnosis and treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550866PMC
http://dx.doi.org/10.7759/cureus.71191DOI Listing

Publication Analysis

Top Keywords

uncontrolled hyperglycemia
12
focal dystonia
8
blood glucose
8
acute focal
4
dystonia presentation
4
presentation uncontrolled
4
hyperglycemia hyperglycemia-induced
4
hyperglycemia-induced involuntary
4
involuntary movements
4
movements hiim
4

Similar Publications

Diabetes mellitus (DM) causes numerous systemic diseases in animals and humans. This may also lead to reproductive problems among individuals of reproductive age. Detrimental effects such as apoptosis in ovarian granulosa cells, degradation of communication proteins, decreased oocyte quality, delayed meiotic maturation, and atrophy are among the increasing evidence that chronic hyperglycemia causes reproductive problems.

View Article and Find Full Text PDF

Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning.

J Zhejiang Univ Sci B

December 2024

Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Article Synopsis
  • Copper sulfate is commonly used in labs, with rare cases of poisoning; only 140 exposures were reported in a year, and five were intentional (Gummin et al., 2023).
  • Severe copper sulfate poisoning can lead to gastrointestinal injury, hemolysis, and muscle damage, but no long-term hyperglycemia has been previously reported.
  • This case study examines the treatment of a patient who ingested a large dose of copper sulfate, resulting in prolonged uncontrolled hyperglycemia and multiple organ dysfunction, stressing the need for careful monitoring and management post-poisoning.
View Article and Find Full Text PDF

Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes.

Kidney Int

December 2024

Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, California, USA. Electronic address:

Chronic kidney disease (CKD) is a highly prevalent global public health issue and can progress to renal failure. Survivors of acute kidney injury (AKI) have an increased risk of progressing to CKD by 8.8-fold and kidney failure by 3.

View Article and Find Full Text PDF
Article Synopsis
  • Obesity and type 2 diabetes pose major public health issues that affect global health significantly.
  • The focus of effective treatments is shifting toward the central nervous system and how it regulates metabolism, especially using incretin-based medications.
  • This review aims to summarize the latest research on the neural pathways related to key receptors involved in metabolic control, specifically glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, and glucagon.
View Article and Find Full Text PDF

Diabetes mellitus (DM) is a chronic metabolic non-communicable disease with the ability to cause serious microvascular and macrovascular complications throughout the body, including in the eye. Diabetic retinopathy (DR), present in one-third of patients with diabetes, is a vision-threatening complication caused by uncontrolled diabetes, which greatly affects the retinal blood vessels and the light-sensitive inner retina, eventually leading to blindness. Several epidemiological studies elucidate that DR can vary by age of onset, duration, types of diabetes, and ethnicity.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!