Background: In diffuse large B-cell lymphoma (DLBCL), bone marrow (BM) involvement includes two types that are concordant involvement and discordant involvement. It has been reported that concordant BM involvement has a worse prognosis than discordant involvement in previous studies. However, the prognostic effects of concordant or discordant BM involvement on DLBCL still need further research. In this work, DLBCL cases with BM involvement were collected and analyzed to better reflect the prognostic implications of concordant and discordant BM involvement.
Methods: We reviewed the cases with newly diagnosed DLBCL and BM involvement from April 2018 to April 2022 in Northern Jiangsu People's Hospital. Overall survival (OS) and progression-free survival (PFS) were accessed by the Kaplan-Meier method and compared between groups by the log-rank test. A multivariate regression analysis based on Cox proportional hazard model was used to test the independent effect of each variable on survival.
Results: In total, 32 patients were included and 15 (46.9%) patients had concordant BM involvement and 17 (53.1%) patients had discordant BM involvement. Compared with the discordant group, the concordant group tended to be older and had elevated lactate dehydrogenase level. The outcome of patients with concordant BM involvement was worse than the discordant subset, including OS (P=0.04) and PFS (P=0.03). Furthermore, the discordant BM involvement was excluded to acquire a BM-adjusted International Prognostic Index (IPI) score. The significance of BM-adjusted IPI scores to predict OS was improved greatly compared with the previous IPI scores (P=0.053 P=0.16). Multivariate analysis showed that the BM-adjusted IPI was an independent predictor for OS [hazard ratio =3.406; 95% confidence interval (CI): 1.145-10.127; P=0.03].
Conclusions: These results highlight the requirement for identifying BM infiltration type accurately and then adjusting the IPI score by excluding discordant BM involvement since concordant involvement can partly predict a poor prognosis of DLBCL with BM involvement other than discordant involvement.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543059 | PMC |
| http://dx.doi.org/10.21037/tcr-24-238 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Longitudinal Twin Growth Discordance Patterns and Adverse Perinatal Outcomes.
Am J Obstet Gynecol
January 2025
Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, United Kingdom; Twin and Multiple Pregnancy Centre for Research and Clinical Excellence, St George's University Hospital, St George's University of London, London, UK; Fetal Medicine Unit, Liverpool Women's Hospital, Liverpool, United Kingdom. Electronic address:
Objective: The objective of this study was to conduct a longitudinal assessment of inter-twin growth and Doppler discordance, to identify possible distinct patterns, and to investigate the predictive value of longitudinal discordance patterns for adverse perinatal outcomes in twin pregnancies.
Methods: This retrospective cohort study included twin pregnancies followed and delivered at a tertiary University Hospital in London (UK), between 2010 and 2023. We included pregnancies with at least three ultrasound assessments after 18 weeks and delivery after 34 weeks' gestation.
Background: Preclinical investigations in Alzheimer's disease (AD) have highlighted the efficacy of gamma sensory stimulation in mitigating AD-related pathologies. Cognito Therapeutics, Inc. (Cambridge, MA) has designed the Sensory Stimulation System for safe at-home usage, to induce EEG-confirmed gamma oscillations as a potential treatment for AD.
View Article and Find Full Text PDFBackground: Positrons Emission Tomography associated with Computed Tomography - PET/CT using the 18F-fluorodeoxyglucose is a well-established exam for the context of dementia evaluation. However, FDG PET is a method still unavailable in most centers and diagnostic accuracy depends on the development of a flowchart that involves proper indication by clinicians and specialized evaluation by nuclear medicine specialists. Our study aims to investigate the indications of FDG PET in the differential diagnosis of dementia in a single center; secondarily, to evaluate how this method aided the diagnostic process.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Background: Although many studies have shown that traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) regardless of their severity, are associated with a significantly increased risk of all-cause dementia, the specific pathophysiological mechanisms that underlie these associations remain poorly understood, resulting in discordance findings among different studies and contradictory claims in the current literature. In this study we investigated the effect of TBI and PTSD on the level of amyloid, tau, as well as markers of small vessel health including white matter hyperintensity and perivascular spaces and consequently assessed their effect on the cognitive function in order to understand the pathways through which TBI and PTSD may result in dementia.
Method: The participants in this study were MCI cases drawn from the ADNI-DOD (n=58).
Background: Cerebrospinal fluid (CSF) is an important source of protein biomarkers for diagnosis, risk stratification, and predicting treatment response in Alzheimer's disease (AD). Proximity to brain parenchyma suggests that CSF proteomic alterations may mirror brain pathological changes. Understanding the evolution of CSF proteomic changes and their alignment with concurrent brain pathology necessitates matched CSF and brain analyses, which are possible using animal models of AD pathology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!