AI Article Synopsis
- Gas gangrene is a severe, often deadly infection caused by Clostridial species, typically arising from injuries, with rare cases of spontaneous infection associated with Clostridium septicum and linked to bowel issues or immune deficiencies.
- A case study details a 71-year-old woman who experienced sudden swelling and pain in her left forearm, leading to emergency surgeries after being diagnosed with C. septicum bacteremia, but ultimately lost function in her arm and required amputation.
- The case emphasizes the critical need for prompt diagnosis and urgent surgical treatment of Clostridial myonecrosis to improve chances of survival.
Article Abstract
Introduction: Gas gangrene is a rare, often lethal infection of soft tissue that is commonly associated with the Clostridial species due to penetrating injuries. Case reports of spontaneous atraumatic gas gangrene due to the Clostridium septicum species are exceedingly rare. Atraumatic C. septicum is notably related to bowel pathologies, immunodeficiencies, and individuals with vascular insufficiency. The rapid progression of Clostridium myonecrosis contributes to its high mortality rates.
Case Report: The authors report a case of a 71-year-old right-hand-dominant female who developed fulminant atraumatic left forearm pain and swelling. The patient was indicated for emergent irrigation and debridement (I&D) of the left upper extremity. She was later found to have C. septicum bacteremia and required multiple I&Ds including the left side of the neck and chest wall. Repeat post-operative examinations revealed no motor function or sensation distal to the elbow and she was subsequently indicated for a proximal trans-humeral amputation.
Conclusion: Although she had a prolonged hospital stay, she progressed well and was eventually discharged to a rehabilitation facility. This case report highlights the importance of early recognition of Clostridial myonecrosis as well as the need for emergent surgical intervention for the patient's survival.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546050 | PMC |
| http://dx.doi.org/10.13107/jocr.2024.v14.i11.4912 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clostridium Septicum: Cause of Gas Gangrene in the Upper Extremity Leading to Proximal Trans-Humeral Amputation, A Review of Clostridium septicum.
J Orthop Case Rep
November 2024
Department of Orthopaedic Surgery, Philadelphia Hand Surgeon PLLC, Lankenau Medical Center, Wynnewood, Pennsylvania.
Article Synopsis
- Gas gangrene is a severe, often deadly infection caused by Clostridial species, typically arising from injuries, with rare cases of spontaneous infection associated with Clostridium septicum and linked to bowel issues or immune deficiencies.
- A case study details a 71-year-old woman who experienced sudden swelling and pain in her left forearm, leading to emergency surgeries after being diagnosed with C. septicum bacteremia, but ultimately lost function in her arm and required amputation.
- The case emphasizes the critical need for prompt diagnosis and urgent surgical treatment of Clostridial myonecrosis to improve chances of survival.
A reverse vaccinomics approach for the designing of novel immunogenic multi-epitope vaccine construct against gas gangrene and related colorectal cancer for Clostridium septicum DSM 7534.
Hum Immunol
November 2024
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan. Electronic address:
Purpose: Costridium septicum, the causative agent of clostridial myonecrosis or gas gangrene, has been linked with colorectal malignancies, particularly tumors of the ascending colon. Due to the pathogen's resistance and the limited understanding of its genomic structure, effective therapeutic strategies are needed. This study focuses on developing a vaccine to address this issue.
View Article and Find Full Text PDFClostridial Infections in Cattle: A Comprehensive Review with Emphasis on Current Data Gaps in Brazil.
Animals (Basel)
October 2024
Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal 68740-970, PA, Brazil.
Clostridial infections in cattle are a significant concern for Brazilian livestock. These diseases are caused by various species of , which are known for their ability to produce potent toxins. Botulism in cattle is a serious and often fatal condition caused by the ingestion of neurotoxins produced by .
View Article and Find Full Text PDF[Fatal course of a fulminant gas gangrene of the right hemithorax].
Unfallchirurgie (Heidelb)
October 2024
Klinik für Unfallchirurgie und Orthopädie, Universitätsklinikum Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.
Article Synopsis
- Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
- Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
- Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Gas gangrene with Clostridium septicum in a neutropenic patient.
Infection
October 2024
Department of Plastic Surgery and Hand Surgery, Cantonal Hospital Aarau, Aarau, Switzerland.
Article Synopsis
- Gas gangrene is a serious infection caused by Clostridium bacteria, often resulting in rapid tissue death and requiring quick, multidisciplinary medical intervention.
- The case describes a 62-year-old woman with neutropenic fever from chemotherapy for breast cancer, who initially showed signs of cellulitis but deteriorated into septic shock despite antibiotic treatment.
- After extensive surgical intervention and adjustment of her antibiotics, the patient stabilized and was eventually discharged for rehabilitation, underscoring the diagnostic and therapeutic challenges associated with infections in immunocompromised individuals.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!