Phytochemical analysis : PCA

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=39523526&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 3952352620241111

1099-15652024Nov10Phytochemical analysis : PCAPhytochem AnalAn Integrative Strategy for Discriminating Quality Markers of Tibetan Medicine Chebulae Fructus Based on Multidimensional Feature Network.10.1002/pca.3463Chebulae Fructus (TCF) is a traditional Chinese medicine and Tibetan medicine with high medicinal value, but its quality control indicators still need clarification. In this study, a strategy was proposed to specify the quality markers (Q-markers) of TCF by constructing a multidimensional feature network that includes dimensions of effectiveness, content, traceability, and specificity. Network pharmacology analysis was performed to validate the effectiveness of the chemical constituents in TCF through creating a TCF-component-disease-target-pathway network. By combining fingerprints analysis with UPLC-QTOF-MS, 17 differential components were identified among 19 batches of TCF samples. Serum pharmacochemical analysis on rats identified seven prototype components absorbed into the blood. The scores for the four dimensions were calculated using these identified components as candidates, and a multidimensional feature network based on the "spider-web" model was constructed. Ultimately, chebulinic acid, ellagic acid, chebulagic acid, methyl gallate, gallic acid, chebulic acid, and trigalloylglucose were clarified as Q-markers of TCF. These Q-markers screened out in this study are closely linked to the efficacy of TCF and can serve as indicator components for quality control of TCF.© 2024 John Wiley & Sons Ltd.LiQian-QianQQSchool of Pharmacy, Lanzhou University, Lanzhou, China.ChenJuanJ0000-0002-1844-0042School of Pharmacy, Lanzhou University, Lanzhou, China.eng2018FY100701Special Foundation for National Science and Technology Basic Resources of China2022GSMPA-KL042022 Project of the State Drug Administration-Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces2024GSMPA-KL062024 Project of the State Drug Administration-Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction PiecesJournal Article20241110

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