AI Article Synopsis
- - The study used bioinformatics to investigate the connections between Crohn's disease (CD) and chronic obstructive pulmonary disease (COPD), identifying 349 common differentially expressed genes (coDEGs) using data from the Gene Expression Omnibus (GEO) microarray dataset.
- - Eight key genes were highlighted as important for immune function and inflammation: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, and MMP9.
- - The research also looked at how these genes relate to immune cell infiltration and identified potential drugs targeting these genes, offering new insights into how CD and COPD interact.
Article Abstract
This study explored the comorbid mechanisms between Crohn's disease (CD) and chronic obstructive pulmonary disease (COPD) using bioinformatics analysis. From the Gene Expression Omnibus (GEO) microarray dataset, 349 common differentially expressed genes (coDEGs) were identified, and 8 shared hub genes were found: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, and MMP9, which were vital for immune function and regulation of inflammatory responses. In addition, the study also analyzed the association between coDEGs and immune cell infiltration using the single-sample gene set enrichment algorithm (ssGSEA). Potential drugs related to these genes were identified using the connectivity map (CMap). These findings provided new perspectives for understanding the interaction between CD and COPD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551177 | PMC |
| http://dx.doi.org/10.1038/s41598-024-78697-5 | DOI Listing |
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