Sensorimotor synchronization (SMS) is the mainly specifically human ability to move in sync with a periodic external stimulus, as in keeping pace with music. The most common experimental paradigm to study its largely unknown underlying mechanism is the paced finger-tapping task, where a participant taps to a periodic sequence of brief stimuli. Contrary to reaction time, this task involves temporal prediction because the participant needs to trigger the motor action in advance for the tap and the stimulus to occur simultaneously, then an error-correction mechanism takes past performance as input to adjust the following prediction. In a different, simpler task, it has been shown that exposure to a distribution of individual temporal intervals creates a "temporal context" that can bias the estimation/production of a single target interval. As temporal estimation and production are also involved in SMS, we asked whether a paced finger-tapping task with period perturbations would show any time-related context effect. In this work we show that a perturbation context can indeed be generated by exposure to period perturbations during paced finger tapping, affecting the shape and size of the resynchronization curve. Response asymmetry is also affected, thus evidencing an interplay between context and intrinsic nonlinearities of the correction mechanism. We conclude that perturbation context calibrates the underlying error-correction mechanism in SMS.
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http://dx.doi.org/10.1038/s41598-024-78786-5 | DOI Listing |
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Department of Non-coding RNAs, Institute of Bioorganic Chemistry of the Polish Academy of Sciences, 61-704 Poznan, Poland. Electronic address:
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Department of Mathematics, Art and Science Faculty, Siirt University, Siirt, Istanbul, Turkey.
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View Article and Find Full Text PDFPhys Rev E
November 2024
School of Science, Constructor University Bremen, Bremen, Germany.
We investigate the influence of the network topology on the asymptotic dynamical patterns, attractors, in a general model of excitable dynamics on signed directed graphs. In this framework, network topology manifests itself as an interplay of positive and negative feedback loops. A small change in a feedback loop, by addition or removal of edges in the graph, can drastically change the dynamical patterns in the network, characterized by the appearance and disappearance of attractors from the attractor space of the network.
View Article and Find Full Text PDFAnnu Rev Biophys
December 2024
1Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA; email:
A complete understanding of protein function and dynamics requires the characterization of the multiple thermodynamic states, including the denatured state ensemble (DSE). Whereas residual structure in the DSE (as well as in partially folded states) is pertinent in many biological contexts, here we are interested in how such structure affects protein thermodynamics. We examine issues related to chain collapse in light of new developments, focusing on potential complications arising from differences in the DSE's properties under various conditions.
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Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
PULSAR (personalized, ultra-fractionated stereotactic adaptive radiotherapy) is the adaptation of stereotactic ablative radiotherapy towards personalized cancer management. It has potential to harness the synergy between radiation therapy and immunotherapy, such as immune checkpoint inhibitors to amplify the anti-tumor immune response. For the first time, we applied a transformer-based attention mechanism to investigate the underlying interactions between combined PULSAR and PD-L1 blockade immunotherapy, based on the preliminary experimental results of a murine cancer model (Lewis Lung Carcinoma, LLC).
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