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CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals. | LitMetric
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CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals.

Marta Del Campo Carlos Quesada Lisa Vermunt Carel F W Peeters Yanaika S Hok-A-Hin Calvin Trieu Anouk den Braber Inge M W Verberk Pieter J Visser Betty M Tijms Wiesje M van der Flier Charlotte E Teunissen

Mol Neurodegener

Neurochemistry Laboratory and Biobank, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Published: November 2024

This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552178PMC
http://dx.doi.org/10.1186/s13024-024-00767-zDOI Listing

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