Computational Neurosurgery in Deep Brain Stimulation.

Computational methods and technologies are critical for neurosurgery in general and in deep brain stimulation (DBS) in particular. They increasingly inform every aspect of clinical DBS therapy, from presurgical planning and hardware implantation to postoperative adjustment of stimulation parameters. Computational methods also occupy a prominent position within the DBS research sphere, where they facilitate efforts to better understand DBS' underlying mechanisms and optimize and individualize its delivery. This chapter provides a high-level overview of the various computational tools and methods that have been applied to DBS. First, we discuss the invaluable contribution of computational neuroimaging (primarily magnetic resonance imaging) to DBS, targeting and the role of postoperative methods of image analysis-specifically, electrode localization, volume of activated tissue modeling, and sweet-spot mapping-in precisely localizing DBS' targets in the brain and discerning optimal treatment loci. We then address the growing field of connectomics, which leverages specific magnetic resonance imaging (MRI) sequences and post-acquisition processing algorithms to explore how DBS operates at the level of brain-wide networks. Next, the search for electrophysiological and imaging-based biomarkers of optimal DBS therapy is explored. We lastly touch on the incipient field of spatial characterization analysis and discuss the ongoing development of adaptive, closed-loop DBS systems.