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Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma.
Nat Cell Biol
January 2025
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Glioblastoma (GBM) is defined by heterogeneous and resilient cell populations that closely reflect neurodevelopmental cell types. Although it is clear that GBM echoes early and immature cell states, identifying the specific developmental programmes disrupted in these tumours has been hindered by a lack of high-resolution trajectories of glial and neuronal lineages. Here we delineate the course of human astrocyte maturation to uncover discrete developmental stages and attributes mirrored by GBM.
View Article and Find Full Text PDFDo epigenetic echoes of gestational diabetes craft a transgenerational path to cardio-metabolic disease?
Eur Heart J
December 2024
Department of Medicine, University of Padova, Via Giustiniani 2, 35128 Padua, Italy.
EZHIP's role in diffuse midline glioma: echoes of oncohistones?
Trends Cancer
December 2024
Cancer Epigenetic Biology and Therapeutics Laboratory, Children's Cancer Institute, Lowy Cancer Centre, Kensington, New South Wales, Australia; School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, New South Wales, Australia; School of Clinical Medicine, Faculty of Medicine & Health, University of New South Wales Sydney, New South Wales, Australia; Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. Electronic address:
Article Synopsis
- - The enhancer of zeste inhibitory protein (EZHIP) plays a role in germ cell development and is recognized as a cancer-testis antigen (CTA) in various cancers, including diffuse midline gliomas (DMGs), where 4% show aberrant expression.
- - Both EZHIP and the H3 K27M mutation—common in DMGs—act as negative regulators of the polycomb repressive complex 2 (PRC2), causing significant changes in the genome's epigenetic regulation.
- - This opinion piece discusses the similarities and differences between EZHIP-DMGs and H3K27M-DMGs, examining their PRC2 inhibition, genetic landscapes, potential cell origins, and future research
Enduring echoes: Post-infectious long-term changes in innate immunity.
Eur J Intern Med
May 2024
Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Germany.
Upon encountering pathogens, the immune system typically responds by initiating an acute and self-limiting reaction, with symptoms subsiding after the pathogen has been cleared. However, long-term post-infectious clinical symptoms can manifest months or even years after the initial infection. 'Trained immunity', the functional reprogramming of innate immune cells through epigenetic and metabolic rewiring, has been proposed as a key concept for understanding these long-term effects.
View Article and Find Full Text PDFThroughout the evolutionary tree, there are gains and losses of morphological features, physiological processes, and behavioral patterns. Losses are perhaps nowhere so prominent as for subterranean organisms, which typically show reductions or losses of eyes and pigment. These losses seem easy to explain without recourse to natural selection.
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