AI Article Synopsis
- Epilepsia Partialis Continua (EPC) is a complex condition that may respond to repetitive transcranial magnetic stimulation (rTMS), which offers both diagnostic and therapeutic potential.
- A review of literature involving cases of EPC treated with rTMS, alongside two in-house patient cases, highlights the varying efficacy of rTMS in reducing seizure activity.
- Results indicate that while some patients experienced no change, low frequency rTMS led to temporary improvements in seizure frequency and motor function in two patients, suggesting its possible role in guiding further treatment.
Article Abstract
Introduction: Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.
Methods: A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.5 Hz) with simultaneous EEG recording with the aim of assessing potential improvement in seizure frequency and severity.
Results: Eight articles were selected comprising 16 patients (15 with EPC and one with continuous myoclonia). In three of these patients, no clinical or EEG changes were noted; the remaining cases showed transitory clinical improvements. We report two patients with EPC, in whom low frequency rTMS was associated with transient reduction in frequency and severity of seizures and improvements in hand function and dexterity. In one of these cases, rTMS suggested a potential target for intracranial recordings, subacute cortical stimulation and localised resection.
Conclusion: In selected patients with EPC, rTMS can be used as a potential diagnostic and therapeutic tool.
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| http://dx.doi.org/10.1016/j.seizure.2024.10.018 | DOI Listing |
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