Quantifying individualized rehabilitation responses and optimizing therapy for each person is challenging. For interventions like treadmill training, there are multiple parameters, such as speed or incline, that can be adjusted throughout sessions. This study evaluates if causal modeling and Bayesian Additive Regression Trees (BART) can be used to accurately track the direct effects of treadmill training on gait. We developed a Directed Acyclic Graph (DAG) to specify the assumed relationship between training input parameters and spatiotemporal outcomes during Short Burst Locomotor Treadmill Training (SBLTT), a therapy designed specifically for children with cerebral palsy (CP). We evaluated outcomes after 24 sessions of SBLTT for simulated datasets of 150 virtual participants and experimental data from four children with CP, ages 4-13 years old. Individual BART models were created from treadmill data of each step. Simulated datasets demonstrated that BART could accurately identify specified responses to training, including strong correlations for step length progression (R = 0.73) and plateaus (R = 0.87). Model fit was stronger for participants with less step-to-step variability but did not impact model accuracy. For experimental data, participants' step lengths increased by 26 ± 13% after 24 sessions. Using BART to control for speed or incline, we found that step length increased for three participants (direct effect: 13.5 ± 4.5%), while one participant decreased step length (-11.6%). SBLTT had minimal effects on step length asymmetry and step width. Tools such as BART can leverage step-by-step data collected during training for researchers and clinicians to monitor progression, optimize rehabilitation protocols, and inform the causal mechanisms driving individual responses.
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http://dx.doi.org/10.1016/j.jbiomech.2024.112397 | DOI Listing |
Nutr Metab (Lond)
December 2024
College of Physical Education and Health Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, Zhejiang Province, China.
Objective: Impaired skeletal muscle glycogen synthesis contributes to insulin resistance (IR). Aerobic exercise reported to ameliorate IR by augmenting insulin signaling, however the detailed mechanism behind this improvement remains unclear. This study investigated whether aerobic exercise enhances glycogen anabolism and insulin sensitivity via EGR-1/PTP1B signaling pathway in skeletal muscle of rats.
View Article and Find Full Text PDFMov Disord
December 2024
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Background: Reduced step length is a hallmark of gait disturbance in people with Parkinson's disease (PD). Although treadmill training is effective for improving step length, the associated neural mechanisms have not been fully investigated. Moreover, exploring the baseline neurophysiological predictors for step length improvement after training could facilitate personalized gait rehabilitation for PD.
View Article and Find Full Text PDFArch Razi Inst
June 2024
Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Alzheimer's is an advanced nervous disorder related to aging. The present study aimed to determine the effect of eight-week aerobic training, along with the consumption of Linalool, Cineole, and β-Bourbonene, on the prevention and improvement of Alzheimer's disease. Mice were randomly assigned to 8 groups: control group, mice induced with Alzheimer's disease treated with β-amyloid (Alzheimer group), Alzheimer's mice treated with bioactive compounds of herbal medicine (Linalool with a concentration of 25 mg/kg, Cineole with a concentration of 100 mg/kg, and β-Bourbonene with a concentration of 10 μg/ml) by gavage for 8 weeks (Alzheimer+Biocompounds group), Alzheimer's mice treated with aerobic exercise with a moderate intensity treadmill for 8 weeks (Alzheimer's+Training group), Alzheimer's mice treated with bioactive compounds of herbal medicine and aerobic exercise for 8 weeks (Alzheimer+Biocompounds+Training group), healthy mice initially treated with bioactive compounds of herbal medication (Linalool with a concentration of 25 mg/kg, Cineol with a concentration of 100 mg/kg, and β-Bourbonene with a concentration of 0.
View Article and Find Full Text PDFComput Biol Med
December 2024
Complex Systems Laboratory, University Politehnica of Bucharest, Bucharest, Romania; Centre for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway; Neuro-SysMed Center, University of Bergen, Bergen, Norway. Electronic address:
Heart rate response to physical activity is widely investigated in clinical and training practice, as it provides information on a person's physical state. For emerging digital phenotyping approaches, there is a need for individualized model estimation. In this study, we propose a zero-poles model and a data-driven evolutionary learning method for identification.
View Article and Find Full Text PDFSchizophr Res
December 2024
Faculty of Health Sciences and Social Care, Molde University College, Molde, Norway; Department of Psychosis and Rehabilitation, Psychiatry Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address:
Unlabelled: Although exercise is medicine for outpatients with schizophrenia, it is unclear if one-year adherence-supported exercise leads to a "tipping point", at which the exercise becomes a routine manifested as life-long training in the patient group.
Methods: Forty-eight outpatients (28 men/20 women: 35 ± 11 (mean ± SD) years) with schizophrenia (ICD-10: F20-29) were randomised to: 1) collaborative care group (TG), performing aerobic interval (AIT; 4 × 4-min treadmill walking/running at ∼90 % peak heart rate) and leg press maximal strength training (MST; 4 × 4 repetitions at ∼90 % maximal strength [1RM]) 2d·wk. for 1-year, supported by transportation and training supervision; or 2) control group (CG).
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