AI Article Synopsis
- Long non-coding RNAs (lncRNAs) play a vital role in regulating gene expression and are linked to tumor initiation and resistance to cancer treatments.
- Research focuses on lncRNAs' influence on non-small cell lung cancer (NSCLC), categorizing them by how they contribute to resistance against chemotherapy, targeted therapy, and radiotherapy.
- Identifying the mechanisms of lncRNAs can help explain varied treatment responses in NSCLC patients and highlight potential new targets for improving therapy effectiveness.
Article Abstract
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression through diverse mechanisms, including regulation of protein localization, sequestration of miRNAs, recruitment of chromatin modifiers, and modulation of signaling pathways. Accumulating evidence highlights their pivotal roles in tumor initiation, progression, and the development of therapeutic resistance. In this review, we comprehensively summarized the existing literature to identify lncRNAs associated with treatment responses in non-small cell lung cancer (NSCLC). Specifically, we categorized these lncRNAs based on their mechanisms of action in mediating resistance to chemotherapy, targeted therapy, and radiotherapy. Our analysis revealed that aberrant expression of various lncRNAs contributes to the development, metastasis, and therapeutic resistance in NSCLC, ultimately leading to poor clinical outcomes. By elucidating the intricate mechanisms through which lncRNAs modulate therapeutic responses, this review aims to provide mechanistic insights into the heterogeneous treatment outcomes observed in NSCLC patients and unveil potential therapeutic targets for overcoming drug resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549762 | PMC |
| http://dx.doi.org/10.1186/s12935-024-03549-1 | DOI Listing |
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