AI Article Synopsis
- Plague, caused by Yersinia pestis, has increased in Inner Mongolia since 2000, responsible for 80% of China's cases in the last five years.
- A study of 585 Y. pestis strains from 1948 to 2021 identified three main lineages, with the 2.MED3 lineage being the most common, along with seven sub-phylogroups displaying different transmission patterns.
- The Xilingol League region serves as a crucial reservoir for the plague bacterium, showing varied transmission dynamics that improve the understanding of its epidemiology and aid in control measures.
Article Abstract
According to WHO, plague, caused by Yersinia pestis, has resurged since 2000. Inner Mongolia, harboring a quarter of China's plague foci, has accounted for 80% of national plague cases in the past five years. Despite its pivotal role in Chinese plague epidemiology, the genetic diversity and transmission dynamics of Y. pestis in this region remain under-investigated. Our analysis of 585 Y. pestis strains from Inner Mongolia (1948-2021) revealed three primary lineages, with 2.MED3 being predominant. We further delineated seven sub-phylogroups in 2.MED3, with 2.MED3.1.2 and 2.MED3.1.4 showing recent dominance. These two subgroups reveal dual transmission patterns: localized short-distance spread and long-distance dispersals over 300 km. Xilingol League is highlighted as a key source and reservoir for Y. pestis, predominantly spreading from central-eastern to southwestern Inner Mongolia, including occasional reverse transmissions. These findings enhance understanding of Y. pestis diversity and transmission in Inner Mongolia, aiding in enhanced surveillance and control measures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550827 | PMC |
| http://dx.doi.org/10.1038/s42003-024-07190-6 | DOI Listing |
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