AI Article Synopsis
- The distinction between viable and post-mortem lesions in forensic medicine is crucial, particularly in advanced decomposition cases.
- Glycophorin A (GPA) is a key immunohistochemical marker that can identify lesion viability for up to six months, though its effectiveness diminishes after 15 days.
- Other markers like tryptase, IL-15, and CD15 have been explored, but their results regarding decomposition remain unclear, leading to a review of their use in forensic investigations.
Article Abstract
The ability to distinguish between viable and post-mortem lesions is crucial in forensic medicine, especially in cases of advanced decomposition. Glycophorin A (GPA) is one of the most studied immunohistochemical markers for assessing lesion viability, with persistence in putrefied tissues up to 6 months. However, its sensitivity decreases beyond 15 days. Other markers such as tryptase, IL-15, CD15, CD45 and matrix metalloproteinases have been tested in decomposition contexts, but the results are inconclusive. This mini review article explores the main studies on immunohistochemical markers, discussing their utility and limitations in forensic investigations of decomposed bodies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.forsciint.2024.112289 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation.
Redox Rep
December 2025
Department of Medical Biochemistry, Tanta Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe-dependent lipid peroxidation.
View Article and Find Full Text PDFProliferative Myositis of the Breast in a Patient with Contralateral Phyllodes Tumor: A Unique Pseudomalignant Lesion.
Ann Ital Chir
December 2024
Department of Pathology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, 34147 İstanbul, Türkiye.
Aim: We report a case of proliferative myositis (PM) of the breast, which is the second reported in the English literature.
Case Presentation: A 49-year-old woman underwent surgery due to a fibroadenoma in the right and phyllodes tumor in the left breast. One month after these surgeries, a right breast mass rapidly grew at the surgical site, and biopsy did not provide a diagnosis.
Primary Retroperitoneal Seminoma-An Uncommon Presentation With Significant Implications.
Case Rep Surg
December 2024
Institute of Surgical Gastroenterology, GI and HPB Oncosurgery and Liver Transplant, Sir Ganga Ram Hospital, New Delhi, India.
Primary retroperitoneal seminoma is an exceedingly rare type of germ cell tumor, accounting for less than 5% of all such tumors. These tumors are typically large at presentation due to their slow growth and the nonspecific nature of symptoms, which often leads to delayed diagnosis. A 40-year-old male presented with intermittent abdominal pain and a palpable lump in the right paraumbilical region.
View Article and Find Full Text PDFComparison of molecular subtype composition between independent sets of primary and brain metastatic small cell lung carcinoma and matched samples.
Lung Cancer
December 2024
Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői, út 26., H-1085 Budapest, Hungary. Electronic address:
Introduction: Recent advances in the subclassification of small cell lung carcinomas (SCLCs) may help to overcome the unmet need for targeted therapies and improve survival. However, limited information is available on how the expression of the subtype markers changes during tumour progression. Our study aimed to compare the expression of these markers in primary and brain metastatic SCLCs.
View Article and Find Full Text PDFClinical characteristics and survival outcomes in patients with pulmonary sarcomatoid carcinoma: a multicenter retrospective study.
Clin Transl Oncol
December 2024
Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Purpose: The clinicopathologic features, mutational status, immunohistochemical markers, and prognosis of Pulmonary sarcomatoid carcinoma (PSC) remain uncertain.
Methods: This study included 81 PSC and 337 lung adenocarcinomas (LUAD). Progression-free survival (PFS), overall survival (OS), and other clinical data were examined.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!