Two new flavonoids, Alpinetin-7-O-[3''--galloyl-4'',6''-hexahydroxy-diphenoyl]---glucose (), Pinocembrin-7--[4''--galloyl]---glucose (), and three known compound () were isolated from Pursh (Saxifragaceae). The structures of all compounds were deduced from their comprehensive spectroscopic analysis including IR, HR-ESI-MS,H NMR,C NMR, DEPT, COSY, HMBC and HMQC. Molecular docking model was used to test the anti-cholestatic liver activities of the isolated compounds, and compounds and showed higher docking scores (-9.90 and -11.27 kcal/mol, respectively) binding with FXR than , and (-8.00, -9.77, -9.10 kcal/mol, respectively), suggesting and exhibited potential anti-cholestatic activities. The present results show that is a potential source of 2 new lead compounds that can be utilised to produce therapeutic drugs for liver diseases upon further studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2024.2426211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways.
Inflammopharmacology
January 2025
Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Maejo 341 Sweet potato (MSP) is a new purple sweet potato variety cultivated in Northern Thailand, but its health benefits are unknown. This study aimed to investigate its antioxidant, anti-inflammatory, and anti-osteoporotic activities, as well as its anthocyanin content. The peel and flesh of MSP were extracted with ethanol and water.
View Article and Find Full Text PDF[Qualitative and quantitative analysis of chemical components of Dracocephalum moldavica based on UPLC-Q-TOF-MS/MS and UPLC].
Zhongguo Zhong Yao Za Zhi
December 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS/MS) was used to rapidly identify the chemical components in Dracocephalum moldavica, and UPLC was employed to determine the content of its main components. MS analysis was performed using an electrospray ionization(ESI) source and data were collected in the negative ion mode. By comparing the retention time and mass spectra of reference compounds, and using a self-built compound database and the PubChem database, 68 compounds were identified from D.
View Article and Find Full Text PDF[Effects of different drying methods on content of main chemical compounds in Callicarpae Nudiflorae Folium].
Zhongguo Zhong Yao Za Zhi
December 2024
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
This study aims to identify the main chemical compounds, investigate the effects of different drying methods on the quality, and determine the appropriate drying method of Callicarpae Nudiflorae Folium. UPLC-UV-Q-TOF-MS was employed to characterize and identify 35 main compounds, including phenylethanoid glycosides, flavonoids, and iridoids in Callicarpae Nudiflorae Folium. A method for the simultaneous determination of 8 compounds with strong UV absorption and high content was established to evaluate the quality of Callicarpae Nudiflorae Folium dried by different methods.
View Article and Find Full Text PDFExtraction and Characterization of Artichoke ( L.) Solid Waste from the Industrial Processing of Fresh-Cut Products for Nutraceutical Use.
Foods
December 2024
Food Toxicology Unit, Department of Life and Environmental Science, University of Cagliari, University Campus of Monserrato, 09042 Cagliari, Italy.
Artichoke ( L.) is an herbaceous perennial plant from the Mediterranean Basin, cultivated as a poly-annual crop in different countries. Artichoke produces a considerable amount of waste at the end of the harvesting season in the field (5.
View Article and Find Full Text PDFMetabolomic and Transcriptomic Analyses of Flavonoid Biosynthesis in Different Colors of Soybean Seed Coats.
Int J Mol Sci
December 2024
Crop Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China.
Soybean has outstanding nutritional and medicinal value because of its abundant protein, oil, and flavonoid contents. This crop has rich seed coat colors, such as yellow, green, black, brown, and red, as well as bicolor variants. However, there are limited reports on the synthesis of flavonoids in the soybean seed coats of different colors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!