AI Article Synopsis
- - Renal ischemia-reperfusion injury (RIRI) results from inadequate blood flow to the kidneys, leading to damage characterized by oxidative stress and inflammation, potentially resulting in acute tubular necrosis and kidney failure.
- - Stem cell-derived exosomes, particularly those from mesenchymal stem cells (MSCs), have shown potential in repairing damage caused by RIRI.
- - This review highlights the significance of MSC exosomes in treating RIRI and discusses avenues for future research in this area.
Article Abstract
Renal ischemia-reperfusion injury (RIRI) is a serious kidney condition that causes significant damage due to lack of blood flow. This injury leads to oxidative stress and inflammation, which can cause acute tubular necrosis and kidney failure. Stem cell-derived exosomes, small vesicles released by stem cells, have shown promise in treating RIRI. Mesenchymal stem cells (MSCs) have been used to mitigate RIRI, and their exosomes have been found to play a crucial role in repairing damaged tissues. This review explores the key roles of exosomes from different sources of MSCs in RIRI, the potential of MSC-derived exosomes in treating this disease, and future research directions.
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| http://dx.doi.org/10.1007/s11255-024-04258-4 | DOI Listing |
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