AI Article Synopsis
- * Buebang 3 CMU showed significantly higher levels of bioactive compounds that promote hair growth and modulate inflammation compared to Sanpatong, with ethanolic extracts exhibiting better efficacy than those extracted using dichloromethane.
- * The findings indicate that the ethanolic Buebang 3 CMU extract enhances hair follicle cell proliferation and activates key hair growth signaling pathways more effectively than traditional treatments like minoxidil and finasteride.
Article Abstract
The bioactive compounds in herbal extracts may provide effective hair loss treatments with fewer side effects compared to synthetic medicines. This study evaluated the effects of Buebang 3 CMU and Sanpatong rice bran extracts, macerated with dichloromethane or 95% ethanol, on hair growth promotion and hair loss prevention. Overall, Buebang 3 CMU extracts contained significantly higher levels of bioactive compounds, including -oryzanol, tocopherols, and various polyphenols such as phytic acid, ferulic acid, and chlorogenic acid, compared to Sanpatong extracts. Additionally, ethanolic extracts demonstrated greater bioactive content and antioxidant activities than those extracted with dichloromethane. These compounds enhanced the proliferation of human hair follicle dermal papilla cells (HFDPCs) by 124.28 ± 1.08% ( < 0.05) and modulated anti-inflammatory pathways by reducing nitrite production to 3.20 ± 0.36 µM ( < 0.05). Key hair growth signaling pathways, including Wnt/β-catenin (CTNNB1), Sonic Hedgehog (SHH, SMO, GLI1), and vascular endothelial growth factor (VEGF), were activated by approximately 1.5-fold to 2.5-fold compared to minoxidil. Also, in both human prostate cancer (DU-145) and HFDPC cells, the ethanolic Buebang 3 CMU extract (Et-BB3-CMU) suppressed , , and expression-key pathways in hair loss-by 2-fold and 1.5-fold more than minoxidil and finasteride, respectively. These findings suggest that Et-BB3-CMU holds promise for promoting hair growth and preventing hair loss.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548315 | PMC |
| http://dx.doi.org/10.3390/plants13213079 | DOI Listing |
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