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Beware of -Benzoyloxybenzamides. | LitMetric

AI Article Synopsis

Article Abstract

Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, . Following resynthesis and stability monitoring, we discovered that is chemically unstable and reacts with DMSO at room temperature. This mode of decomposition is likely general for this class of compound, and we urge caution for their use in drug discovery research.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548001PMC
http://dx.doi.org/10.3390/molecules29215143DOI Listing

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