Stereodivergent Synthesis of Aldol Products Using Pseudo-C Symmetric -benzyl-4-(trifluoromethyl)piperidine-2,6-dione.

The present article describes the successful performance of crossed aldol reactions of the CF-containing pseudo-C symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the -products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding -isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.