AI Article Synopsis
- Gastric cancer (GC) is a prevalent cancer with most patients diagnosed at advanced stages, highlighting a need for better treatment options.
- The tumor microenvironment (TME) plays a crucial role in GC by influencing tumor cell behavior through interactions with inflammatory cells, fibroblasts, and immune cells.
- This review explores the TME's components and their signaling pathways, offering insights for developing new therapies aimed at controlling GC progression and metastasis.
Article Abstract
Gastric cancer (GC) is one of the most common cancers worldwide. Most patients are diagnosed at the progressive stage of GC, and progress in the development of effective anti-GC drugs has been insufficient. The tumor microenvironment (TME) regulates various functions of tumor cells, and interactions between the cellular and molecular components of the TME-e.g., inflammatory cells, fibroblasts, vasculature cells, and innate and adaptive immune cells-promote the aggressiveness of cancer cells and dissemination to distant organs. This review summarizes the roles of various TME cells and molecules in regulating the malignant progression and metastasis of GC. We also address the important roles of signaling pathways in mediating the interaction between cancer cells and the different components of the GC TME. Finally, we discuss the implications of these molecular mechanisms for developing novel and effective therapies targeting molecular and cellular components of the GC TME to control the malignant progression of GC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546171 | PMC |
| http://dx.doi.org/10.3390/ijms252111735 | DOI Listing |
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