AI Article Synopsis
- The study focused on analyzing red blood cell (RBC) changes in 88 hyperthyroid cats without other diseases to better understand how factors like serum thyroxine (T4) levels, age, and sex influence these changes.
- Among the cats, varying conditions were noted: 12 had erythrocytosis, 4 had anemia (likely due to undiagnosed illnesses), while a few exhibited macrocytosis and microcytosis, with a notable connection between high RBC counts and reduced mean corpuscular volume (MCV).
- The findings suggest that erythrocytosis could be linked to microcytosis development, potentially influenced by the interactions of hepcidin, erythropoietin, and thyroid
Article Abstract
Background: There is only a limited number of studies that show alterations in erythrocytes in feline hyperthyroidism. Discrepancies between the findings of these studies may be caused by the presence of concurrent diseases and the use of various haematological analysers.
Methods: This study analysed changes in red blood cells (RBCs) in 88 hyperthyroid cats without concurrent diseases, to identify associations between observed changes and to assess the influence of serum thyroxine (T4) concentration, cat age, and sex, on RBC changes.
Results: Among the eighty-eight hyperthyroid cats, erythrocytosis was observed in twelve, anaemia in four, macrocytosis in two, and microcytosis in three. Three of the four cases of anaemia probably resulted from concurrent unrecognised disease. Interestingly, all cases of microcytosis were recognized in cats that had erythrocytosis. This study identified a moderate negative correlation between RBC count and mean corpuscular volume (MCV; r = -0.57, < 0.001). Concluding, it appears that erythrocytosis may be a response to the development of microcytosis. The correlation between RBC count and MCV in hyperthyroid cats may result from the increased action of hepcidin and erythropoietin coupled with the decreased action of thyroid-stimulating hormone (TSH).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545726 | PMC |
| http://dx.doi.org/10.3390/ani14213136 | DOI Listing |
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Article Synopsis
- The study focused on analyzing red blood cell (RBC) changes in 88 hyperthyroid cats without other diseases to better understand how factors like serum thyroxine (T4) levels, age, and sex influence these changes.
- Among the cats, varying conditions were noted: 12 had erythrocytosis, 4 had anemia (likely due to undiagnosed illnesses), while a few exhibited macrocytosis and microcytosis, with a notable connection between high RBC counts and reduced mean corpuscular volume (MCV).
- The findings suggest that erythrocytosis could be linked to microcytosis development, potentially influenced by the interactions of hepcidin, erythropoietin, and thyroid
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