AI Article Synopsis
- Kinase inhibitors are valuable in cancer therapy but face challenges in visualizing tumor environments, limiting their effectiveness.
- Conjugating kinase inhibitors with fluorophores offers a dual approach for cancer diagnosis and treatment, enabling better imaging of tumors while applying therapeutic measures.
- The review examines the design and structure of these multimodal inhibitors, emphasizing their potential for enhanced kinase tracking and inhibition through bioimaging, which could inspire future development of new theranostic agents.
Article Abstract
Kinase inhibitors are potent therapeutic agents in cancer treatment, but their effectiveness is frequently restricted by the inability to image the tumor microenvironment. To address this constraint, kinase inhibitor-fluorophore conjugates have emerged as promising theranostic agents, allowing for simultaneous cancer diagnosis and treatment. These conjugates are gaining attention for their ability to visualize malignant tissues and concurrently enhance therapeutic interventions. This review explores the design principles governing the development of multimodal inhibitors, highlighting their potential as platforms for kinase tracking and inhibition via bioimaging. The structural aspects of constructing such theranostic agents are critically analyzed. This work could shed light on this intriguing field and provide adequate impetus for developing novel theranostic compounds based on small molecule inhibitors and fluorophores.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545566 | PMC |
| http://dx.doi.org/10.3390/cancers16213667 | DOI Listing |
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