This paper proposes a Composition Piecewise Memory Polynomial (CPMP) digital predistortion model based on a Vector Switched (VS) behavioral model to address the challenges of severe nonlinearity and strong memory effects in wideband power amplifiers (PAs). To tackle this issue, two thresholds are calculated and used to segment the envelope values of the input signal according to the nonlinear distortion characteristics of the PA. In this approach, a Generalized Memory Polynomial (GMP) model is employed for the lower segment, a Memory Polynomial (MP) model is employed for the middle segment, and a higher-order GMP model is employed for the upper segment. By sharing the fundamental MP among the proposed segmented models and leveraging a design methodology that configures different cross terms, memory depths, and polynomial orders for each segment, this model achieves superior linearization performance while simultaneously reducing the computational complexity associated with model extraction. The experimental results demonstrate that the adjacent channel power ratio (ACPR) of the predistorted PA output signal using the proposed model improves from -36 dBc to -54 dBc, matching the performance of the GMP model. Furthermore, this performance is 0.5 dBc better than the Piecewise Dynamic Deviation Reduction (PDDR) and Decomposed Vector Rotation (DVR) models. Notably, the complexity of the proposed parameter extraction process is 28.8% of the DVR model, 21.79% of the GMP model, and 12.83% of the PDDR model.
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http://dx.doi.org/10.3390/s24216941 | DOI Listing |
Front Immunol
January 2025
Institute of Cell Genetics, Department for Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Nuclear receptors regulate hematopoietic stem cells (HSCs) and peripheral immune cells in mice and humans. The nuclear orphan receptor NR2F6 (EAR-2) has been shown to control murine hematopoiesis. Still, detailed analysis of the distinct stem cell, myeloid, and lymphoid progenitors in the bone marrow in a genetic loss of function model remains pending.
View Article and Find Full Text PDFFront Chem
January 2025
Department of Surgery, Pirogov Russian National Research Medical University, Moscow, Russia.
Cannabinoid and stilbenoid compounds derived from were screened against eight specific fungal protein targets to identify potential antifungal agents. The proteins investigated included Glycosylphosphatidylinositol (GPI), Enolase, Mannitol-2-dehydrogenase, GMP synthase, Dihydroorotate dehydrogenase (DHODH), Heat shock protein 90 homolog (Hsp90), Chitin Synthase 2 (CaChs2), and Mannitol-1-phosphate 5-dehydrogenase (M1P5DH), all of which play crucial roles in fungal survival and pathogenicity. This research evaluates the binding affinities and interaction profiles of selected cannabinoids and stilbenoids with these eight proteins using molecular docking and molecular dynamics simulations.
View Article and Find Full Text PDFBr J Pharmacol
January 2025
Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Background And Purpose: Chronic kidney disease (CKD) is characterised by inflammation, which can lead to tubular atrophy and fibrosis. The molecular mechanisms are not well understood. In this study, we investigated the functional role of the cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) signalling in renal inflammation and fibrosis.
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
Department of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China.
Background: Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.
Methods: CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification.
Int J Biochem Cell Biol
January 2025
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:
Introduction: Non-healing wounds pose significant challenges and require effective therapeutic interventions. Extracellular vesicles (EVs) have emerged as promising cell-free therapeutic agents in tissue regeneration. However, the functional differences between different subpopulations of EVs in wound healing remain understudied.
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