AI Article Synopsis

  • Acute kidney injury (AKI) is a frequent issue in chronic kidney disease (CKD) patients in cardiac ICUs, prompting a study to find predictors for AKI in this population.
  • The MORCOR-TURK trial involved over 3,100 patients, with 615 CKD patients analyzed; AKI occurred in 46% of these patients during their hospital stay.
  • Key predictors for developing AKI included decompensated heart failure, types of coronary interventions, elevated troponin levels, and the need for mechanical ventilation, suggesting the need for personalized treatment strategies to prevent AKI.

Article Abstract

Background: Acute kidney injury (AKI) is a common complication in chronic kidney disease (CKD) patients in the cardiac intensive care unit (cardiac ICU). In this study, we aimed to identify predictors of AKI in CKD patients treated in the cardiac ICU for cardiovascular diseases.

Methods: The MORCOR-TURK trial was conducted as a multicenter, prospective, cross-sectional, and noninterventional investigation. A total of 3157 patients treated in the cardiac ICU were enrolled from 50 centers over the course of one month. In this subgroup analysis, 615 patients with CKD treated in the cardiac ICU for cardiovascular disease were included in the study. The primary outcome of this study was the development of AKI. During hospitalization, patients who developed AKI were identified.

Results: AKI developed in 288 patients (46%). After multivariable analysis, decompensated heart failure (OR: 3.72, p = 0.005), primary percutaneous coronary intervention (OR: 3.75, p = 0.004), non-primary percutaneous coronary intervention (OR: 2.85, p = 0.033), troponin levels (OR: 1.04, p = 0.031), and need for mechanical ventilation (OR: 3.11, p < 0.001) were identified as independent predictors of AKI development in CKD patients.

Conclusion: Our efforts to identify AKI predictors in cardiac ICU patients with CKD have yielded directly applicable results in clinical practice. AKI can be prevented by developing personalized strategies to follow up and treat cardiac ICU patients with CKD who have decompensated heart failure, are undergoing percutaneous coronary intervention (primary and non-primary), have high troponin levels, and need mechanical ventilation.

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Source
http://dx.doi.org/10.1007/s40620-024-02127-yDOI Listing

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