Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22). Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53. This forum article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate decisions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tcb.2024.10.006 | DOI Listing |
Publication Analysis
Top Keywords
mdm4 exon
8
exon skipping
8
mdm4
4
skipping dysfunctional
4
dysfunctional ribosome
4
ribosome assembly
4
assembly studies
4
studies revealed
4
revealed nucleolar
4
nucleolar stress
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!