Traces of convergent evolution left in the structure of EgtB-IV.

Structure

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address:

Published: November 2024

The enzymatically regioselective catalyzed incorporation of cysteine sulfoxide into histidine generates physiologically important antioxidants such as ergothioneine and ovothiol. In this issue of Structure, Ireland et al. report the crystal structure of EgtB-IV, which provides insights into the convergent evolution of sulfoxide synthase.

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http://dx.doi.org/10.1016/j.str.2024.10.006DOI Listing

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