Trained immunity in the bone marrow: Hub of autoimmunity.

Cell Stem Cell

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Published: November 2024

An inappropriate induction of trained immunity in the bone marrow progenitors of immune cells has been described to underlie chronic inflammatory processes. Mills and colleagues' recently published paper in Cell Stem Cell shows that maladaptive trained immunity drives inflammation in autoimmune processes, opening a new area of research in autoimmunity.

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Source
http://dx.doi.org/10.1016/j.stem.2024.10.008DOI Listing

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