AI Article Synopsis
- - The study explored how the presence of fasciculation potentials (FPs) in electromyography (EMG) and uric acid (UA) levels relate to survival in amyotrophic lateral sclerosis (ALS) patients, revealing a link between these markers and disease progression.
- - Researchers classified 89 ALS patients into three groups based on their progression speed: fast (less than 1 year), average (1 to 3 years), and slow (3 years or more), finding significant differences in FPs and UA levels across these groups.
- - Higher percentages of affected muscles with FPs and lower UA levels were strongly correlated with faster disease progression and shorter survival, emphasizing the need for better prognostic indicators in ALS.
Article Abstract
Some prognostic biomarkers of amyotrophic lateral sclerosis (ALS) have been described; however, they are inadequate for satisfactorily predicting individual patient outcomes. Fasciculation potentials (FPs) on electromyography (EMG) are useful for the early diagnosis of ALS, and complex FPs are associated with shorter survival in ALS. In this study, we investigated the relationship between the proportion of muscles with FPs, biochemical markers, and the prognosis of ALS. 89 Patients with ALS were retrospectively classified into three groups based on the interval from onset to death or tracheostomy (less than 1 year: fast progression; from 1 year to less than 3 years: average progression; 3 years or more: slow progression). We performed statistical analysis of the electrophysiological findings, including the percentage of examined muscles with FPs, and biochemical markers evaluated on admission. Patients with fast ALS progression had a higher percentage of muscles with FPs (93.1% vs. 37.9%, P<0.001) and lower uric acid (UA) levels (male: 4.19 mg/dl vs 5.55 mg/dl, P<0.001; female: 3.71 mg/dl vs 5.41 mg/dl, P<0.001) than patients with slow progression. Survival curves demonstrated a relationship between these factors and the survival time in patients with ALS. Furthermore, UA levels were correlated with the percentage of muscles with FPs. Our electrophysiological findings suggest that ALS presents with multisystem neurological manifestations, and these manifestations differed among the groups classified by disease progression. The percentage of muscles with FPs on EMG and serum UA levels were especially associated with the prognosis of ALS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548741 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0313307 | PLOS |
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Article Synopsis
- - The study explored how the presence of fasciculation potentials (FPs) in electromyography (EMG) and uric acid (UA) levels relate to survival in amyotrophic lateral sclerosis (ALS) patients, revealing a link between these markers and disease progression.
- - Researchers classified 89 ALS patients into three groups based on their progression speed: fast (less than 1 year), average (1 to 3 years), and slow (3 years or more), finding significant differences in FPs and UA levels across these groups.
- - Higher percentages of affected muscles with FPs and lower UA levels were strongly correlated with faster disease progression and shorter survival, emphasizing the need for better prognostic indicators in ALS.
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