A novel strategy for boron-mediated C-H hydroxylation of 1-phenyl-1-pyrazoles is presented. The protocol exhibits high efficiency and site exclusivity, offering the corresponding phenols in moderate to excellent yields with wide functional group tolerance under simple and metal-free conditions. Moreover, the hydroxylated products show good derivatization applications. This route provides a convenient and practical way to obtain functionalized 1-phenyl-1-pyrazoles.
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| http://dx.doi.org/10.1021/acs.joc.4c02105 | DOI Listing |
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