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Tailored peptide nanomaterials for receptor targeted prostate cancer imaging. | LitMetric

Tailored peptide nanomaterials for receptor targeted prostate cancer imaging.

Nanoscale

Departments of Chemistry and Departments of Medical Imaging and Oncology, University of Western Ontario, University of Western Ontario, Centre, 1151 Richmond St, London, ON, N6A 3K7, Canada.

Published: December 2024

AI Article Synopsis

  • * These nanotubes, characterized using electron microscopy, are about 28 nm in diameter and are designed to enhance imaging efficacy by incorporating a cancer-targeting peptide and a fluorescent dye.
  • * Testing shows that the nanotubes specifically bind to prostate cancer cells, suggesting their potential to improve molecular imaging techniques for prostate cancer and possibly other types of cancer.

Article Abstract

We report the development of a peptide-based optical nanoprobe specifically tailored for prostate cancer imaging. The imaging probe is comprised of cyclic peptide nanotubes, formed the aqueous co-assembly of four cyclic D,L-alternating octapeptides. The inherent properties of these cyclic building blocks have been carefully selected to enhance their efficacy in imaging applications, through the addition of a cancer targeting peptide and a fluorescent dye. Comprehensive characterization using scanning electron microscopy (FESEM) and low-voltage transmission electron microscopy (LV-TEM) confirms the formation of nanotubes through co-assembly of the cyclic peptides. The resulting nanotubes show an average diameter of 28 nm. Circular dichroism (CD) spectroscopy validates the formation of stable beta-sheet hydrogen bonding structures at both 20 and 37 °C, ensuring their suitability for biomedical applications. Evaluation of PSMA-binding specificity of the resulting peptide nanotubes is assessed using confocal fluorescence microscopy demonstrating receptor-mediated uptake in prostate cancer cells. We anticipate this strategy will provide the basis for the utilization of co-assembled systems for advancing molecular imaging techniques in prostate cancer and other cancers.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d4nr03273jDOI Listing

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