The journal retracts the article titled "Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells" [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546878 | PMC |
| http://dx.doi.org/10.3390/ijms252212012 | DOI Listing |
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RETRACTED: Al-Wahaibi et al. Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells. 2020, , 4138.
Int J Mol Sci
November 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
The journal retracts the article titled "Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells" [...
View Article and Find Full Text PDFInterplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.
Biomed Pharmacother
June 2024
The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, Amsterdam 1066 CX, the Netherlands.
Article Synopsis
- Transmembrane drug transporters significantly influence how drugs are processed in the body, affecting their effectiveness and safety.
- Researchers created a new mouse model (Bab12) lacking certain drug transporters to study their impacts on drug levels and interactions.
- Findings indicated varying effects of transporter deficiencies on different drugs, highlighting the importance of transporter interplay in drug development and the potential for using the Bab12 model to enhance pharmacological studies.
Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.
Pharmacol Res
April 2023
The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:
Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized Oatp2b1 knockout (single Slco2b1 and combination Slco1a/1b/2b1) and humanized hepatic and intestinal OATP2B1 transgenic mouse models. While viable and fertile, these strains exhibited a modestly increased body weight.
View Article and Find Full Text PDFColon Targeted Eudragit Coated Beads Loaded with Optimized Fluvastatin-Scorpion Venom Conjugate as a Potential Approach for Colon Cancer Therapy: In Vitro Anticancer Activity and In Vivo Colon Imaging.
J Pharm Sci
December 2022
Department of Pharmaceutics, Faculty of Pharmacy, Minia University, El-Minia 61519, Egypt. Electronic address:
Preclinical studies suggest that most of statins or 3‑hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors possess pleiotropic anticancer activity. The aim of the present work was to investigate the conjugation of the statin fluvastatin (FLV) with scorpion venom (SV), a natural peptide with proven anticancer properties, to enhance FLV cytotoxic activity and prepare colon targeted FLV-SV nanoconjugate beads for management of colon cancer. Response surface design was applied for the optimization of FLV-SV nanoconjugates.
View Article and Find Full Text PDFMastoparan, a Peptide Toxin from Wasp Venom Conjugated Fluvastatin Nanocomplex for Suppression of Lung Cancer Cell Growth.
Polymers (Basel)
December 2021
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Lung cancer has a very low survival rate, and non-small cell lung cancer comprises around 85% of all types of lung cancers. Fluvastatin (FLV) has demonstrated the apoptosis and suppression of tumor-cell proliferation against lung cancer cells in vitro. Drug-peptide nanoconjugates were found to enhance the cytotoxicity of anti-cancer drugs.
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