AI Article Synopsis
- An advanced electrochemiluminescence (ECL) detection system has been developed, combining a bipolar electrode system with MXene material for improved electrical conductivity and redox-active surface area.
- The system utilizes the ROR1 antibody to enhance ECL signals through an immunoassay with a modified Ag triangle, enabling sensitive cancer detection.
- The low-cost immunosensors demonstrated high sensitivity over a wide range (10 fg/mL to 1 µg/mL) and achieved approximately 90% accuracy in diagnosing real cancer samples.
Article Abstract
An electrochemiluminescence (ECL) detection system is presented integrated with a bipolar electrode system for sensitive cancer diagnosis. In order to achieve the highest electrical conductivity and redox-active surface area, MXene was chosen as the material for the bipolar electrode. As part of the detection process, the anodic pole of the bipolar electrode was modified with the receptor tyrosine kinase like orphan receptor 1 (ROR1) antibody, followed by an immunoassay using the ROR1 antibody-modified Ag triangle that was identified as significantly enhancing ECL. We measured the ECL of luminol using the anode pole of BPE as an analytical signal in the presence of HO. Additionally, 3D-printed microchannels were used to fabricate the BPE system, to reduce the quantity of sample required. It has been shown that the present immunosensors are low-cost and sensitive in detecting types of cancer, with an extended linear range of 10 fg mL to 1 µg mL in the analysis of synthetic samples and achieving an accuracy of ~ 90% in diagnosing ten unknown real samples.
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| http://dx.doi.org/10.1007/s00604-024-06815-1 | DOI Listing |
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