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DOKing tumor progression in ccRCC.
J Cancer
October 2024
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Randomized controlled trial of an individual blended cognitive behavioral therapy to reduce psychological distress among distressed colorectal cancer survivors: The COloRectal canceR distrEss reduCTion trial.
Psychooncology
January 2024
Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands.
Objective: Colorectal cancer survivors (CRCS) often experience high levels of distress. The objective of this randomized controlled trial was to evaluate the effect of blended cognitive behavior therapy (bCBT) on distress severity among distressed CRCS.
Methods: CRCS (targeted N = 160) with high distress (Distress Thermometer ≥5) between 6 months and 5 years post cancer treatment were randomly allocated (1:1 ratio) to receive bCBT, (14 weeks including five face-to-face, and three telephone sessions and access to interactive website), or care as usual (CAU).
Reasons for non-participation in a psychological intervention trial for distress in colorectal cancer survivors.
Psychooncology
April 2023
Department of Medical Psychology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Objective: High psychological distress is reported by one third of colorectal cancer survivors (CRCS). However, intervention studies for CRCS have reported low participation rates. In this study, reasons for non-participation and low uptake in a psychological intervention trial were investigated.
View Article and Find Full Text PDFPlasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment.
Cancer Sci
November 2022
Cancer Proteomics Group, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Article Synopsis
- Researchers studied liquid biomarkers in patients with EGFR mutation-positive non-small-cell lung cancer receiving gefitinib, analyzing plasma samples to find proteins linked to tumor response and survival outcomes.
- Out of 1769 proteins identified, several were correlated with tumor reduction, progression-free survival (PFS), and overall survival (OS), with notable involvement of immune response regulators.
- CD8α and DOK3 emerged as significant markers, indicating that patients with strong T-cell and B-cell immunity may have better responses to gefitinib therapy.
Study protocol of the CORRECT multicenter trial: the efficacy of blended cognitive behavioral therapy for reducing psychological distress in colorectal cancer survivors.
BMC Cancer
July 2018
Radboud Institute for Health Sciences, Department of Medical Psychology Radboud University Medical Center, (840), P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Background: Approximately one third of the colorectal cancer survivors (CRCS) experience high levels of psychological distress. Common concerns experienced by CRCS include distress related to physical problems, anxiety, fear of cancer recurrence (FCR) and depressive symptoms. However, psychological interventions for distressed CRCS are scarce.
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